PMID- 21970456
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20111025
IS  - 1521-0669 (Electronic)
IS  - 0888-0018 (Linking)
VI  - 28
IP  - 8
DP  - 2011 Nov
TI  - Cytotoxic function of umbilical cord blood natural killer cells: relevance to 
      adoptive immunotherapy.
PG  - 640-6
LID - 10.3109/08880018.2011.613092 [doi]
AB  - Decreased graft-versus-host disease (GVHD), ease of accessibility, and sustained 
      engraftment encourage the use of umbilical cord blood (UCB) as an alternative 
      source to bone marrow for immune reconstitution in children with leukemia. 
      Natural killer (NK) cells rapidly expand after stem cell transplantation and are 
      important for regulating GVHD and providing graft-versus-leukemia (GVL) effects. 
      This review highlights the phenotypic and functional differences between UCB NK 
      cells and adult peripheral blood (APB) NK cells, and discusses the possible 
      therapeutic benefit of using UCB NK cells for adoptive immunotherapy in leukemia. 
      Alloreactive NK cells show potent cytotoxic activities against human leukocyte 
      antigen (HLA)-nonidentical leukemic cells and reduce leukemia relapses. The 
      higher numbers of NK progenitors in UCB makes it a convenient source for ex vivo 
      expansion of UCB NK cells for posttransplant treatment. UCB NK cells readily 
      respond to interleukin-15, which may greatly enhance their antitumor effect. 
      Activation and expansion protocols for UCB NK cells are currently being 
      developed.
FAU - Lin, Syh-Jae
AU  - Lin SJ
AD  - Division of Asthma, Allergy, and Rheumatology, Department of Pediatrics, Chang 
      Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan, 
      Taiwan. sjlino@adm.cgmh.org.tw
FAU - Kuo, Ming-Ling
AU  - Kuo ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111004
PL  - England
TA  - Pediatr Hematol Oncol
JT  - Pediatric hematology and oncology
JID - 8700164
SB  - IM
MH  - Cytotoxicity, Immunologic/*immunology
MH  - Fetal Blood/*cytology/*immunology
MH  - Humans
MH  - *Immunotherapy, Adoptive
MH  - Killer Cells, Natural/*immunology
MH  - Leukemia/*immunology/pathology/*therapy
EDAT- 2011/10/06 06:00
MHDA- 2012/09/14 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.3109/08880018.2011.613092 [doi]
PST - ppublish
SO  - Pediatr Hematol Oncol. 2011 Nov;28(8):640-6. doi: 10.3109/08880018.2011.613092. 
      Epub 2011 Oct 4.