PMID- 21971502
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20151119
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 290
IP  - 2-3
DP  - 2011 Dec 18
TI  - Dose-dependent behavioral disturbances after a single neonatal Bisphenol A dose.
PG  - 187-94
LID - 10.1016/j.tox.2011.09.006 [doi]
AB  - Bisphenol A is widely used in polymer products for food and beverage packaging, 
      baby bottles, dental sealants, and fillings, adhesives, protective coatings, 
      flame retardants, water supply pipes, and compact discs, and is found in the 
      environment and in placental tissue, fetuses and breast milk. We have recently 
      reported that neonatal exposure to other environmental pollutants can induce 
      persistent aberrations in spontaneous behavior and also affect learning and 
      memory functions in the adult animal. Furthermore, recent reports indicate that 
      pre- and perinatal exposure to Bisphenol A can induce neurotoxic effects. The 
      present study indicates that a single exposure to Bisphenol A on postnatal day 10 
      can alter adult spontaneous behavior and cognitive function in mice, effects that 
      are both dose-response related and long-lasting/irreversible. Earlier studies on 
      neonatal exposure to persistent organic pollutants (POPs) have shown the 
      cholinergic system to be a target of neurotoxicity, but here only minor effects 
      on the nicotine-induced behavior was seen. Furthermore, Morris swim-maze and the 
      elevated plus-maze did not reveal any effects on spatial learning and 
      anxiety-like behaviors. The present findings show similarities with effects 
      earlier reported after pre- and perinatal exposure to Bisphenol A, and also with 
      effects seen after a single postnatal exposure to other POPs, such as PBDEs, PCBs 
      and PFCs.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Viberg, Henrik
AU  - Viberg H
AD  - Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, 
      SE-75236 Uppsala, Sweden. Henrik.Viberg@ebc.uu.se
FAU - Fredriksson, Anders
AU  - Fredriksson A
FAU - Buratovic, Sonja
AU  - Buratovic S
FAU - Eriksson, Per
AU  - Eriksson P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110928
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phenols)
RN  - 6M3C89ZY6R (Nicotine)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/*drug effects
MH  - Benzhydryl Compounds
MH  - Cognition/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/administration & dosage/*toxicity
MH  - Female
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Mice
MH  - Neurotoxicity Syndromes/*etiology
MH  - Nicotine/pharmacology
MH  - Phenols/administration & dosage/*toxicity
MH  - Time Factors
EDAT- 2011/10/06 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2011/09/16 00:00 [revised]
PHST- 2011/09/19 00:00 [accepted]
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - S0300-483X(11)00345-3 [pii]
AID - 10.1016/j.tox.2011.09.006 [doi]
PST - ppublish
SO  - Toxicology. 2011 Dec 18;290(2-3):187-94. doi: 10.1016/j.tox.2011.09.006. Epub 
      2011 Sep 28.