PMID- 21971845
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20211020
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 28
IP  - 6
DP  - 2012 Aug
TI  - Myocardial area at risk after ST-elevation myocardial infarction measured with 
      the late gadolinium enhancement after scar remodeling and T2-weighted cardiac 
      magnetic resonance imaging.
PG  - 1455-64
LID - 10.1007/s10554-011-9952-9 [doi]
AB  - To evaluate the myocardial area at risk (AAR) measured by the endocardial surface 
      area (ESA) method on late gadolinium enhancement (LGE) cardiovascular magnetic 
      resonance (CMR) when applied after scar remodeling (3 months after index 
      infarction) compared to T2-weighted CMR imaging. One hundred and sixty nine 
      patients with ST-elevation myocardial infarction, treated with primary 
      percutaneous coronary intervention, underwent one CMR within 1 week after index 
      treatment to determine the AAR with T2-weighted imaging and a second scan 3 
      months after to measure AAR with the ESA method. There was a moderate correlation 
      between the two methods (r = 0.86; P < 0.001). The AAR was significantly higher 
      measured with T2-weighted imaging than with the ESA methods (32 +/- 11% of left 
      ventricle (LV) vs. 26 +/- 10%LV; P < 0.001). The mean difference was 6 +/- 6%LV. 
      Furthermore, the mean difference between the two methods was statistical higher 
      in the patients with myocardial salvage index >/=0.90 than in the remaining 
      patients (9 +/- 8%LV vs. 6 +/- 5%LV; P = 0.02). The ESA method performed after scar 
      remodeling (3 months following STEMI) yields significantly lower AAR's and 
      myocardial salvage indices compared to the T2-weighted method. Therefore, 
      T2-weighted CMR plus LGE is the method of choice to assess AAR and myocardial 
      salvage index using CMR. However, the ESA method is an easy and valid method for 
      determining AAR, which can be used in settings where T2-weighted imaging has not 
      been obtained in the acute phase.
FAU - Lonborg, Jacob
AU  - Lonborg J
AD  - Department of Cardiology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, 
      Denmark. Jacoblonborg@gmail.com
FAU - Engstrom, Thomas
AU  - Engstrom T
FAU - Mathiasen, Anders B
AU  - Mathiasen AB
FAU - Vejlstrup, Niels
AU  - Vejlstrup N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111005
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Aged
MH  - Cicatrix
MH  - *Contrast Media
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/pathology/physiopathology/therapy
MH  - Myocardium/*pathology
MH  - *Organometallic Compounds
MH  - Percutaneous Coronary Intervention
MH  - Predictive Value of Tests
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2011/10/06 06:00
MHDA- 2013/03/23 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/06/07 00:00 [received]
PHST- 2011/09/27 00:00 [accepted]
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - 10.1007/s10554-011-9952-9 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2012 Aug;28(6):1455-64. doi: 10.1007/s10554-011-9952-9. 
      Epub 2011 Oct 5.