PMID- 21972057
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20131121
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 26
IP  - 4
DP  - 2012 Apr
TI  - The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in 
      NC/Nga mice.
PG  - 594-9
LID - 10.1002/ptr.3577 [doi]
AB  - The fruits of Cudrania tricuspidata are a medicinal herb in Korea, known for its 
      antiatherosclerotic and antiinflammatory effects. Atopic dermatitis (AD) is a 
      chronic inflammatory skin disease characterized by the influx of lymphocytes into 
      the dermis. Using an animal model of AD, we assessed whether C. tricuspidata 
      suppresses the development of AD-like skin lesions. Cudrania tricuspidata was 
      administered orally to NC/Nga mice with Dermatophagoides-farinae-induced AD-like 
      lesions for 49 days. The effects of C. tricuspidata were assessed by measuring 
      clinical symptoms, swelling of the skin on the back and ears, and plasma 
      concentrations of mTARC (mouse thymus and activation regulated chemokine), 
      histamine and immunoglobulin E (IgE). We found that C. tricuspidata (60 
      mg/kg/day) inhibited the development of AD-like skin lesions, reduced skin 
      dermatitis scores and inhibited the histological changes induced by repeated 
      application of D. farinae. In addition, C. tricuspidata inhibited the increases 
      in plasma concentrations of mTARC, histamine and IgE induced by D. farinae. These 
      findings indicate that C. tricuspidata inhibits the development of AD-like skin 
      lesions induced by repeated applications of D. farinae in sensitized NC/Nga by 
      suppressing plasma concentrations of mTARC, histamine and IgE.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Lee, Hoyoung
AU  - Lee H
AD  - Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, 
      Daejeon 305-811, Korea.
FAU - Ha, Hyekyung
AU  - Ha H
FAU - Lee, Jun Kyung
AU  - Lee JK
FAU - Seo, Chang-Seob
AU  - Seo CS
FAU - Lee, Nam-Hun
AU  - Lee NH
FAU - Jung, Da-Young
AU  - Jung DY
FAU - Park, Sang-Joon
AU  - Park SJ
FAU - Shin, Hyeun Kyoo
AU  - Shin HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111004
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Ccl17 protein, mouse)
RN  - 0 (Chemokine CCL17)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology
MH  - Chemokine CCL17/blood
MH  - Dermatitis, Atopic/*drug therapy/parasitology/pathology
MH  - Dermatophagoides farinae/immunology/pathogenicity
MH  - Drug Evaluation, Preclinical
MH  - Fruit/*chemistry
MH  - Histamine/blood
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mice
MH  - Molecular Structure
MH  - Moraceae/*chemistry
MH  - Prednisolone/blood
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2011/10/06 06:00
MHDA- 2012/08/15 06:00
CRDT- 2011/10/06 06:00
PHST- 2010/08/08 00:00 [received]
PHST- 2011/05/08 00:00 [accepted]
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.1002/ptr.3577 [doi]
PST - ppublish
SO  - Phytother Res. 2012 Apr;26(4):594-9. doi: 10.1002/ptr.3577. Epub 2011 Oct 4.