PMID- 21972261
OWN - NLM
STAT- MEDLINE
DCOM- 20120712
LR  - 20211020
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 23
IP  - 10
DP  - 2011 Oct
TI  - SCAR mediates light-induced root elongation in Arabidopsis through photoreceptors 
      and proteasomes.
PG  - 3610-26
LID - 10.1105/tpc.111.088823 [doi]
AB  - The ARP2/3 complex, a highly conserved nucleator of F-actin, and its activator, 
      the SCAR complex, are essential for growth in plants and animals. In this 
      article, we present a pathway through which roots of Arabidopsis thaliana 
      directly perceive light to promote their elongation. The ARP2/3-SCAR complex and 
      the maintenance of longitudinally aligned F-actin arrays are crucial components 
      of this pathway. The involvement of the ARP2/3-SCAR complex in light-regulated 
      root growth is supported by our finding that mutants of the SCAR complex subunit 
      BRK1/HSPC300, or other individual subunits of the ARP2/3-SCAR complex, showed a 
      dramatic inhibition of root elongation in the light, which mirrored reduced 
      growth of wild-type roots in the dark. SCAR1 degradation in dark-grown wild-type 
      roots by constitutive photomorphogenic 1 (COP1) E3 ligase and 26S proteasome 
      accompanied the loss of longitudinal F-actin and reduced root growth. Light 
      perceived by the root photoreceptors, cryptochrome and phytochrome, suppressed 
      COP1-mediated SCAR1 degradation. Taken together, our data provide a biochemical 
      explanation for light-induced promotion of root elongation by the ARP2/3-SCAR 
      complex.
FAU - Dyachok, Julia
AU  - Dyachok J
AD  - Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 
      73401, USA.
FAU - Zhu, Ling
AU  - Zhu L
FAU - Liao, Fuqi
AU  - Liao F
FAU - He, Ji
AU  - He J
FAU - Huq, Enamul
AU  - Huq E
FAU - Blancaflor, Elison B
AU  - Blancaflor EB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111004
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
RN  - 0 (Actin-Related Protein 2-3 Complex)
RN  - 0 (Actins)
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Cysteine Proteinase Inhibitors)
RN  - 0 (Leupeptins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Photoreceptors, Plant)
RN  - 0 (Proteasome Inhibitors)
RN  - 0 (SCAR1 protein, Arabidopsis)
RN  - 11121-56-5 (Phytochrome)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
RN  - EC 3.4.99.- (ATP dependent 26S protease)
RN  - RF1P63GW3K (benzyloxycarbonylleucyl-leucyl-leucine aldehyde)
SB  - IM
MH  - Actin-Related Protein 2-3 Complex/genetics/*metabolism
MH  - Actins/metabolism
MH  - Arabidopsis/genetics/*physiology/radiation effects/ultrastructure
MH  - Arabidopsis Proteins/genetics/*metabolism
MH  - Cysteine Proteinase Inhibitors/pharmacology
MH  - Darkness
MH  - Leupeptins/pharmacology
MH  - Light
MH  - Light Signal Transduction/physiology
MH  - Microfilament Proteins/genetics/*metabolism
MH  - Mutation
MH  - Phenotype
MH  - Photoreceptors, Plant/genetics/*metabolism
MH  - Phytochrome/genetics/metabolism
MH  - Plant Components, Aerial/genetics/physiology/radiation effects/ultrastructure
MH  - Plant Roots/genetics/*physiology/radiation effects/ultrastructure
MH  - Plants, Genetically Modified
MH  - Proteasome Endopeptidase Complex/genetics/*metabolism
MH  - Proteasome Inhibitors
MH  - Protein Binding
MH  - Seedlings/genetics/physiology/radiation effects/ultrastructure
MH  - Ubiquitin-Protein Ligases/genetics/metabolism
PMC - PMC3229138
EDAT- 2011/10/06 06:00
MHDA- 2012/07/13 06:00
PMCR- 2011/10/04
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/07/13 06:00 [medline]
PHST- 2011/10/04 00:00 [pmc-release]
AID - tpc.111.088823 [pii]
AID - 088823 [pii]
AID - 10.1105/tpc.111.088823 [doi]
PST - ppublish
SO  - Plant Cell. 2011 Oct;23(10):3610-26. doi: 10.1105/tpc.111.088823. Epub 2011 Oct 
      4.