PMID- 21972705
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20140108
IS  - 0450-2167 (Print)
IS  - 0450-2167 (Linking)
IP  - 1
DP  - 2010
TI  - [The role of matrixmetalloproteinases in the tumor growth and metastasis].
PG  - 44-9
AB  - Many authors have described the role ofmatrixmetalloproteinases (MMP) in tumor 
      invasion. MMPs are a family of zinc-dependent endopeptidases, which through 
      degradation of the extracellular matrix (ECM) and the basal membrane induce tumor 
      spread and metastasis. There are more than 20 enzymes classified into 6 groups: 
      Collagenases (MMP-1,-8,-13 and -18), Gelatinases (MMP-2 and MMP-9, Stromelysins 
      (MMP-3,-7,-10,-11,-26,-27), Elastases (MMP-12), Membrane type specific MMPs 
      (MMP-14,-15,-16,-17,-24 H -25) and other MMPs (MMP-19,-20,-28,-21,-22,-23). Many 
      authors have demonstrated a positive correlation between the pattern of MMP 
      expression and the tumor invasive and metastatic potential including: rectal and 
      gastric cancer, lung carcinoma, breast, ovarian, prostate, thyroid cancer and 
      brain tumors. The increased expression of tissue inhibitors of MMPS (TIMPs) is a 
      response against the tumor progression leading to suppression of the MMP-activity 
      and preservation of the ECM integrity. Due to the dual role of TIMPs, which 
      together with MT1-MMP activate pro-MMPs it is possible that the correlation 
      between activator/inhibitor is the one defining the tumor growth and metastasis.
FAU - Velinov, N
AU  - Velinov N
FAU - Poptodorov, G
AU  - Poptodorov G
FAU - Gabrovski, N
AU  - Gabrovski N
FAU - Gabrovski, St
AU  - Gabrovski S
LA  - bul
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Bulgaria
TA  - Khirurgiia (Sofiia)
JT  - Khirurgiia
JID - 0376355
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Matrix Metalloproteinases/genetics/*metabolism
MH  - Neoplasm Metastasis/genetics/pathology
MH  - Neoplasms/*enzymology/genetics/metabolism/*pathology
MH  - Tissue Inhibitor of Metalloproteinases/genetics/metabolism
EDAT- 2010/01/01 00:00
MHDA- 2011/10/19 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
PST - ppublish
SO  - Khirurgiia (Sofiia). 2010;(1):44-9.