PMID- 21973240
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20221207
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 53
IP  - 5
DP  - 2012 May
TI  - Association of genetic variations in mTOR with risk of childhood acute 
      lymphoblastic leukemia in a Chinese population.
PG  - 947-51
LID - 10.3109/10428194.2011.628062 [doi]
AB  - The mammalian target of rapamycin (mTOR) is an important protein kinase 
      regulating cell survival and apoptosis. To determine whether genetic variations 
      in mTOR are associated with risk of acute lymphoblastic leukemia (ALL) in Chinese 
      children, we genotyped two tag single nucleotide poymorphisms (SNPs) in mTOR 
      (rs2536 and rs2295080) in a case-control study. We observed that the variant 
      genotype TC of mTOR rs2536 was associated with a significantly decreased risk of 
      childhood ALL (adjusted odds ratio [OR] = 0.67, 95% confidence interval [CI] = 
      0.46-0.96), and the association was more pronounced in high-risk ALL and 
      T-phenotype ALL groups. Additionally, we found that the combined genotypes TC/CC 
      decreased the risk of ALL only in the high-risk ALL group (adjusted OR = 0.54, 
      95% CI = 0.32-0.91) and T-phenotype ALL group (adjusted OR = 0.29, 95% CI = 
      0.10-0.84). These results suggest that the mTOR rs2536 polymorphism is involved 
      in the susceptibility to childhood ALL in a Chinese population.
FAU - Huang, Lizhen
AU  - Huang L
AD  - Department of Hematology and Oncology, Nanjing Medical University, Nanjing, 
      China.
FAU - Huang, Jie
AU  - Huang J
FAU - Wu, Peng
AU  - Wu P
FAU - Li, Qian
AU  - Li Q
FAU - Rong, Liucheng
AU  - Rong L
FAU - Xue, Yao
AU  - Xue Y
FAU - Lu, Qin
AU  - Lu Q
FAU - Li, Jie
AU  - Li J
FAU - Tong, Na
AU  - Tong N
FAU - Wang, Meilin
AU  - Wang M
FAU - Zhang, Zhengdong
AU  - Zhang Z
FAU - Fang, Yongjun
AU  - Fang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111205
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adolescent
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - Polymorphism, Single Nucleotide
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology/*genetics
MH  - Risk
MH  - TOR Serine-Threonine Kinases/*genetics
EDAT- 2011/10/07 06:00
MHDA- 2012/10/30 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 10.3109/10428194.2011.628062 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2012 May;53(5):947-51. doi: 10.3109/10428194.2011.628062. Epub 
      2011 Dec 5.