PMID- 21976674
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 118
IP  - 24
DP  - 2011 Dec 8
TI  - Reduced-intensity conditioning with combined haploidentical and cord blood 
      transplantation results in rapid engraftment, low GVHD, and durable remissions.
PG  - 6438-45
LID - 10.1182/blood-2011-08-372508 [doi]
AB  - We conducted a 45 patient prospective study of reduced-intensity conditioning 
      (RIC) and transplantation of unrelated umbilical cord blood (UCB) and CD34(+) 
      stem cells from a haploidentical family member. Median age was 50 years; weight 
      was 80 kg. Fifty-eight percent had active disease. Neutrophil engraftment 
      occurred at 11 days (interquartile range [IQR], 9-15) and platelet engraftment at 
      19 days (IQR, 15-33). In the majority of patients, early haploidentical 
      engraftment was replaced by durable engraftment of UCB by 100 days, with regular 
      persistence of minor host and/or haplo-hematopoiesis. Percentage of 
      haplochimerism at day 100 correlated with the haplo-CD34 dose (P = .003). 
      Cumulative incidence of acute GVHD (aGVHD) was 25% and chronic GVHD (cGVHD) was 
      5%. Actuarial survival at 1 year was 55%, progression-free survival (PFS) was 
      42%, nonrelapse mortality (NRM) was 28%, and relapse was 30%. RIC and haplo-cord 
      transplantation results in fast engraftment of neutrophils and platelets, low 
      incidences of aGVHD and cGVHD, low frequency of delayed opportunistic infections, 
      reduced transfusion requirements, shortened length of hospital stay, and 
      promising long-term outcomes. UCB cell dose had no impact on time to 
      hematopoietic recovery. Therefore, UCB selection can prioritize matching, and 
      better matched donors can be identified rapidly for most patients. This study is 
      registered at http://clinicaltrials.gov as NCI clinical trial no. NCT00943800.
FAU - Liu, Hongtao
AU  - Liu H
AD  - Section of Hematology/Oncology, Department of Medicine, University of Chicago, 
      Chicago, IL, USA.
FAU - Rich, Elizabeth S
AU  - Rich ES
FAU - Godley, Lucy
AU  - Godley L
FAU - Odenike, Olatoyosi
AU  - Odenike O
FAU - Joseph, Loren
AU  - Joseph L
FAU - Marino, Susana
AU  - Marino S
FAU - Kline, Justin
AU  - Kline J
FAU - Nguyen, Vu
AU  - Nguyen V
FAU - Cunningham, John
AU  - Cunningham J
FAU - Larson, Richard A
AU  - Larson RA
FAU - del Cerro, Paula
AU  - del Cerro P
FAU - Schroeder, Linda
AU  - Schroeder L
FAU - Pape, Lisa
AU  - Pape L
FAU - Stock, Wendy
AU  - Stock W
FAU - Wickrema, Amittha
AU  - Wickrema A
FAU - Artz, Andrew S
AU  - Artz AS
FAU - van Besien, Koen
AU  - van Besien K
LA  - eng
SI  - ClinicalTrials.gov/NCT00943800
GR  - K24 CA116471/CA/NCI NIH HHS/United States
GR  - K24 CA 116471/CA/NCI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111005
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, CD34)
SB  - IM
MH  - Adult
MH  - Adult Stem Cells/metabolism/transplantation
MH  - Aged
MH  - Antigens, CD34/metabolism
MH  - *Cord Blood Stem Cell Transplantation/adverse effects
MH  - Female
MH  - *Graft Survival
MH  - Graft vs Host Disease/*epidemiology/immunology/prevention & control
MH  - Haplotypes
MH  - Humans
MH  - Illinois/epidemiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Peripheral Blood Stem Cell Transplantation/adverse effects
MH  - Pilot Projects
MH  - Remission Induction
MH  - Survival Analysis
MH  - *Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Young Adult
PMC - PMC3236125
EDAT- 2011/10/07 06:00
MHDA- 2012/02/15 06:00
PMCR- 2012/12/08
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
PHST- 2012/12/08 00:00 [pmc-release]
AID - S0006-4971(20)40513-0 [pii]
AID - 2011/372508 [pii]
AID - 10.1182/blood-2011-08-372508 [doi]
PST - ppublish
SO  - Blood. 2011 Dec 8;118(24):6438-45. doi: 10.1182/blood-2011-08-372508. Epub 2011 
      Oct 5.