PMID- 21976710
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20211020
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Social cognitive impairments and negative symptoms in schizophrenia: are there 
      subtypes with distinct functional correlates?
PG  - 186-96
LID - 10.1093/schbul/sbr125 [doi]
AB  - Social cognitive impairments and negative symptoms are core features of 
      schizophrenia closely associated with impaired community functioning. However, 
      little is known about whether these are independent dimensions of illness and if 
      so, whether individuals with schizophrenia can be meaningfully classified based 
      on these dimensions (SANS) and potentially differentially treated. Five social 
      cognitive measures plus Scale for the Assessment of Negative Symptoms (SANS) and 
      Positive and Negative Syndrome Scale (PANSS) scores in a sample of 77 outpatients 
      produced 2 distinct factors--a social cognitive factor and a negative symptom 
      factor. Factor scores were used in a cluster analysis, which yielded 3 
      well-defined groupings--a high negative symptom group (HN) and 2 low negative 
      symptom groups, 1 with higher social cognition (HSC) and 1 with low social 
      cognition (LSC). To make these findings more practicable for research and 
      clinical settings, a rule of thumb for categorizing using only the 
      Mayer-Salovey-Caruso Emotional Intelligence Test and PANSS negative component was 
      created and produced 84.4% agreement with the original cluster groups. An 
      additional 63 subjects were added to cross validate the rule of thumb. When 
      samples were combined (N = 140), the HSC group had significantly better quality 
      of life and Global Assessment of Functioning (GAF) scores, higher rates of 
      marriage and more hospitalizations. The LSC group had worse criminal and 
      substance abuse histories. With 2 common assessment instruments, people with 
      schizophrenia can be classified into 3 subgroups that have different barriers to 
      community integration and could potentially benefit from different treatments.
FAU - Bell, Morris D
AU  - Bell MD
AD  - VA Connecticut Healthcare System, Rehabilitation Research and Development 
      Service, West Haven, CT, USA. morris.bell@yale.edu
FAU - Corbera, Silvia
AU  - Corbera S
FAU - Johannesen, Jason K
AU  - Johannesen JK
FAU - Fiszdon, Joanna M
AU  - Fiszdon JM
FAU - Wexler, Bruce E
AU  - Wexler BE
LA  - eng
GR  - KO2 MH01296/MH/NIMH NIH HHS/United States
GR  - MH61493/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111005
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adult
MH  - Cluster Analysis
MH  - Cognition Disorders/diagnosis/*physiopathology
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life
MH  - Schizophrenia/classification/diagnosis/*physiopathology
MH  - *Schizophrenic Psychology
MH  - *Social Perception
PMC - PMC3523908
EDAT- 2011/10/07 06:00
MHDA- 2013/06/14 06:00
PMCR- 2014/01/01
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - sbr125 [pii]
AID - 10.1093/schbul/sbr125 [doi]
PST - ppublish
SO  - Schizophr Bull. 2013 Jan;39(1):186-96. doi: 10.1093/schbul/sbr125. Epub 2011 Oct 
      5.