PMID- 21977859
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20220316
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 31
IP  - 3
DP  - 2011 Sep
TI  - Effects of the modified linggui zhugan decoction (see text) combined with 
      short-term very low calorie diets on glycemic control in newly diagnosed type 2 
      diabetics.
PG  - 185-8
AB  - OBJECTIVE: To evaluate the effects of the modified Linggui Zhugan Decoction (see 
      text) combined with short-term very low calorie diets (VLCDs) on glycemic control 
      in newly diagnosed type 2 diabetes mellitus (T2DM) patients. METHODS: A total of 
      20 subjects with newly diagnosed T2DM were treated with the modified Linggui 
      Zhugan Decoction (one-month administration) combined with short-term VLCDs (5 
      days), and 3-months follow-up. A standard 75-g oral-glucose-tolerance test (OGTT) 
      indexes fasting plasma glucose (FPG), post-prandial 0.5 h and 2 h plasma glucose 
      (P0.5hPG, P2hPG), glycated hemoglobin A(1c) (GHbA(1c)), body weight, body mass 
      index (BMI), insulin function, insulin resistance index, incidence of 
      hypoglycemia, and the liver and renal functions were evaluated before and after 
      treatment. Correlations of BMI with insulin function and insulin resistance were 
      also assessed. RESULTS: After the treatment, the patients' plasma glucose 
      decreased steadily, FPG decreased from 5.8 +/- 0.9 mmol/L at pre-treatment to 5.0 
      +/- 0.6 mmol/L at 3-months follow-up (P < 0.05), and P2hPG decreased from 11.7 
      +/- 3.8 mmol/L at pre-treatment to 6.9 +/- 0.9 mmol/L at 3-months follow-up (P < 
      0.01). The level of GHbA(1c) declined from (6.47 +/- 1.24)% at pre-treatment to 
      (6.14 +/- 0.99)% at 3-months follow-up (P < 0.01). Body weight and BMI also 
      declined significantly. Insulin resistance index was improved obviously and no 
      event of hypoglycemia occurred. Part of the patients companied with fatty liver 
      had a transient increase in hepatic transaminase during the treatment, but it 
      turned to normal after the treatment. CONCLUSIONS: The modified Linggui Zhugan 
      Decoction combined with short-term VLCDs can be safely implemented for steady 
      glycemic control in newly diagnosed T2DM patients.
FAU - Chen, Ding-Sheng
AU  - Chen DS
AD  - Department of Chinese Medicine, First Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, Guangdong 510080, China.
FAU - Ke, Bin
AU  - Ke B
FAU - Huang, Ying-Juan
AU  - Huang YJ
FAU - Meng, Jun
AU  - Meng J
FAU - Zhang, Jun-Jie
AU  - Zhang JJ
FAU - Chen, Ze-Xiong
AU  - Chen ZX
FAU - Michalsen, Andreas
AU  - Michalsen A
FAU - Qin, Jian
AU  - Qin J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 0 (Blood Glucose)
RN  - 0 (Plant Extracts)
RN  - 0 (ling-gui-zhu-gan decoction)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/drug effects
MH  - Body Mass Index
MH  - Body Weight/drug effects
MH  - *Caloric Restriction
MH  - Diabetes Mellitus, Type 2/*diet therapy/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plant Extracts/*therapeutic use
EDAT- 2011/10/08 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1016/s0254-6272(11)60038-1 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2011 Sep;31(3):185-8. doi: 10.1016/s0254-6272(11)60038-1.