PMID- 21978916
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20240406
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 34
IP  - 1
DP  - 2012 Jan-Feb
TI  - Prenatal exposure to MDMA alters noradrenergic neurodevelopment in the rat.
PG  - 206-13
LID - 10.1016/j.ntt.2011.09.005 [doi]
AB  - 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) binds with high affinity to the 
      norepinephrine transporter (NET), making the noradrenergic system a potential 
      target during fetal exposure. Recent data indicate that adult rats that had been 
      prenatally exposed to MDMA display persistent deficits in working memory and 
      attention; behaviors consistent with abnormal noradrenergic signaling in the 
      forebrain. The present study was designed to investigate whether prenatal 
      exposure to MDMA from embryonic days 14-20 affects the structure and/or function 
      of the noradrenergic system of the rat on postnatal day 21. Offspring that were 
      prenatally exposed to MDMA exhibited an increase in noradrenergic fiber density 
      in the prelimbic region of the prefrontal cortex and the CA1 region of the 
      hippocampus that was not accompanied by an increase in the number of 
      noradrenergic neurons in the locus coeruleus. Direct tissue autoradiography using 
      tritiated nisoxetine demonstrated that while NET binding was not altered in the 
      prelimbic cortex, the dentate gyrus, or the locus coeruleus, it was increased in 
      the CA1, CA2, and CA3 regions of the hippocampus. Basal levels of norepinephrine 
      were increased in the prefrontal cortex and the nucleus accumbens of MDMA-exposed 
      rats, as compared to saline-treated controls. These findings indicate that 
      prenatal exposure to MDMA results in structural changes in the noradrenergic 
      system as well as functional alterations in NE neurotransmission in structures 
      that are critical in attentional processing.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Thompson, V B
AU  - Thompson VB
AD  - Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, USA. 
      valerie.thompson@emory.edu
FAU - Koprich, J B
AU  - Koprich JB
FAU - Chen, E Y
AU  - Chen EY
FAU - Kordower, J H
AU  - Kordower JH
FAU - Terpstra, B T
AU  - Terpstra BT
FAU - Lipton, J W
AU  - Lipton JW
LA  - eng
GR  - 1R21DA019261/DA/NIDA NIH HHS/United States
GR  - R21 DA019261/DA/NIDA NIH HHS/United States
GR  - R21 DA019261-01/DA/NIDA NIH HHS/United States
GR  - 1R01DA017399/DA/NIDA NIH HHS/United States
GR  - R01 DA017399-05/DA/NIDA NIH HHS/United States
GR  - R01 DA017399/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110928
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Neurons/*drug effects/*pathology
MH  - Adrenergic Uptake Inhibitors/*toxicity
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Count
MH  - Cell Differentiation/drug effects/physiology
MH  - Disease Models, Animal
MH  - Female
MH  - Male
MH  - Microscopy/methods
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Nerve Fibers, Myelinated/pathology
MH  - Neurogenesis/*drug effects/physiology
MH  - Neurotoxicity Syndromes/pathology/*physiopathology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/metabolism/pathology/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC3268906
MID - NIHMS328605
COIS- Conflict of Interest Statement: The authors declare that there are no conflicts 
      of interest.
EDAT- 2011/10/08 06:00
MHDA- 2012/10/16 06:00
PMCR- 2013/01/01
CRDT- 2011/10/08 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/09/16 00:00 [revised]
PHST- 2011/09/20 00:00 [accepted]
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - S0892-0362(11)00192-9 [pii]
AID - 10.1016/j.ntt.2011.09.005 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2012 Jan-Feb;34(1):206-13. doi: 10.1016/j.ntt.2011.09.005. 
      Epub 2011 Sep 28.