PMID- 21978942
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20140325
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 100
IP  - 3
DP  - 2012 Jan
TI  - Modulatory effects of low-dose MDMA on cocaine-induced locomotor activity and 
      place conditioning in rats.
PG  - 377-81
LID - 10.1016/j.pbb.2011.09.007 [doi]
AB  - Methylenedioxymethamphetamine (MDMA; "Ecstasy") is commonly abused by humans in 
      environments such as nightclubs and rave parties where other drugs of abuse are 
      readily available. Despite the popularity of polysubstance abuse among 
      recreational MDMA users, relatively few controlled experimental studies have 
      documented the neurobehavioral effects of MDMA in combination with other abused 
      substances. This study employed conditioned place preference procedures (CPP) to 
      assess the locomotor activating and place conditioning effects of acute 
      concurrent administration of MDMA (1.5 or 3.0 mg/kg) and cocaine (10 or 20 mg/kg) 
      in rats. Results indicate that low dose MDMA can enhance the locomotor and 
      conditioned rewarding effects of cocaine. These findings may have important 
      implications for understanding the contribution of serotonergic-dopaminergic 
      interactions in the abuse liability of MDMA when used in combination with cocaine 
      or other psychostimulant drugs.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Panos, John J
AU  - Panos JJ
AD  - Western Michigan University, Kalamazoo, MI 49008, USA.
FAU - Baker, Lisa E
AU  - Baker LE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110924
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Hallucinogens)
RN  - 0 (Serotonin Agents)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Stimulants/administration & dosage/agonists/antagonists & 
      inhibitors/toxicity
MH  - Cocaine/administration & dosage/*agonists/*antagonists & inhibitors/toxicity
MH  - Cocaine-Related Disorders/*physiopathology
MH  - Conditioning, Operant
MH  - Dopamine Uptake Inhibitors/administration & dosage/*agonists/*antagonists & 
      inhibitors/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Dyskinesia, Drug-Induced/*drug therapy/etiology
MH  - Hallucinogens/administration & dosage/pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reward
MH  - Serotonin Agents/administration & dosage/pharmacology
EDAT- 2011/10/08 06:00
MHDA- 2012/05/05 06:00
CRDT- 2011/10/08 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/09/12 00:00 [revised]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
AID - S0091-3057(11)00314-5 [pii]
AID - 10.1016/j.pbb.2011.09.007 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2012 Jan;100(3):377-81. doi: 10.1016/j.pbb.2011.09.007. 
      Epub 2011 Sep 24.