PMID- 21979832
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20131121
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 22
IP  - 8
DP  - 2011 Dec
TI  - Antidepressant-like effects of 3,4-methylenedioxymethamphetamine in an animal 
      model of depression.
PG  - 758-65
LID - 10.1097/FBP.0b013e32834d0f05 [doi]
AB  - Increased synaptic serotonin (5-hydroxytryptamine) levels may underlie 
      antidepressant-like effects of 3,4-methylenedioxymethamphetamine (MDMA) that may 
      be more prominent in subjects with mood disturbance. The Flinders Sensitive Line 
      (FSL) strain is an important animal model of depression. These rats are more 
      immobile in the forced swimming test (FST), and their immobility is reversed by 
      known antidepressants after prolonged administration. The objective of this study 
      was to determine whether MDMA administration has a dose-dependent 
      antidepressant-like effect in this animal model of depression. The effects of 
      MDMA at 5 and 10 mg/kg following single and repeated administration were assessed 
      in FSL rats using the FST. Sprague-Dawley rats were used as a control. During 
      both FST sessions, saline-treated FSL rats were significantly more immobile than 
      Sprague-Dawley rats (P<0.001). Acute MDMA administration had a dose-dependent 
      antidepressant-like effect in FSL rats, which was most evident after 10 mg/kg. 
      This effect was diminished after repeated administration. Methamphetamine 2 
      mg/kg, which was used as a positive control for locomotor activity induction, did 
      not affect the depressive-like state in FSL rats. There were no changes in the 
      cortical levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid after 
      treatments. It is concluded that MDMA exhibited an antidepressant-like effect in 
      FSL rats, which was most evident following acute administration.
FAU - Majumder, Irina
AU  - Majumder I
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      South Australia, Australia. irina.majumder@unisa.edu.au
FAU - White, Jason M
AU  - White JM
FAU - Irvine, Rodney J
AU  - Irvine RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Central Nervous System Stimulants)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/pharmacology/therapeutic use
MH  - Animals
MH  - Antidepressive Agents/pharmacology/*therapeutic use
MH  - Brain/*drug effects/metabolism
MH  - Central Nervous System Stimulants/pharmacology/therapeutic use
MH  - Depressive Disorder/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Methamphetamine/pharmacology/therapeutic use
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Swimming
EDAT- 2011/10/08 06:00
MHDA- 2013/02/06 06:00
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 10.1097/FBP.0b013e32834d0f05 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2011 Dec;22(8):758-65. doi: 10.1097/FBP.0b013e32834d0f05.