PMID- 21980019
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20211020
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 22
IP  - 8
DP  - 2012 Aug
TI  - Laterality of temporoparietal causal connectivity during the prestimulus period 
      correlates with phonological decoding task performance in dyslexic and typical 
      readers.
PG  - 1923-34
LID - 10.1093/cercor/bhr265 [doi]
AB  - We examined how effective connectivity into and out of the left and right 
      temporoparietal areas (TPAs) to/from other key cortical areas affected 
      phonological decoding in 7 dyslexic readers (DRs) and 10 typical readers (TRs) 
      who were young adults. Granger causality was used to compute the effective 
      connectivity of the preparatory network 500 ms prior to presentation of nonwords 
      that required phonological decoding. Neuromagnetic activity was analyzed within 
      the low, medium, and high beta and gamma subbands. A mixed-model analysis 
      determined whether connectivity to or from the left and right TPAs differed 
      across connectivity direction (in vs. out), brain areas (right and left inferior 
      frontal and ventral occipital-temporal and the contralateral TPA), reading group 
      (DR vs. TR), and/or task performance. Within the low beta subband, better 
      performance was associated with increased influence of the left TPA on other 
      brain areas across both reading groups and poorer performance was associated with 
      increased influence of the right TPA on other brain areas for DRs only. DRs were 
      also found to have an increase in high gamma connectivity between the left TPA 
      and other brain areas. This study suggests that hierarchal network structure 
      rather than connectivity per se is important in determining phonological decoding 
      performance.
FAU - Frye, Richard E
AU  - Frye RE
AD  - Division of Child Neurology, Arkansas Children's Hospital, Little Rock, AR 72202, 
      USA. REFrye@uams.edu
FAU - Liederman, Jacqueline
AU  - Liederman J
FAU - McGraw Fisher, Janet
AU  - McGraw Fisher J
FAU - Wu, Meng-Hung
AU  - Wu MH
LA  - eng
GR  - NS046565/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111006
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Adult
MH  - Brain Mapping/methods
MH  - Dyslexia/*physiopathology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Magnetoencephalography
MH  - Male
MH  - Neural Pathways/*physiopathology
MH  - Reading
MH  - Task Performance and Analysis
MH  - Young Adult
PMC - PMC3394369
EDAT- 2011/10/08 06:00
MHDA- 2012/11/07 06:00
PMCR- 2011/10/06
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PHST- 2011/10/06 00:00 [pmc-release]
AID - bhr265 [pii]
AID - 10.1093/cercor/bhr265 [doi]
PST - ppublish
SO  - Cereb Cortex. 2012 Aug;22(8):1923-34. doi: 10.1093/cercor/bhr265. Epub 2011 Oct 
      6.