PMID- 21983295
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20111214
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 199
DP  - 2011 Dec 29
TI  - Both olfactory epithelial and vomeronasal inputs are essential for activation of 
      the medial amygdala and preoptic neurons of male rats.
PG  - 225-34
LID - 10.1016/j.neuroscience.2011.09.051 [doi]
AB  - Chemosensory inputs signaling volatile and nonvolatile molecules play a pivotal 
      role in sexual and social behavior in rodents. We have demonstrated that 
      olfactory preference in male rats, that is, attraction to receptive female odors, 
      is regulated by the medial amygdala (MeA), the cortical amygdala (CoA), and the 
      preoptic area (POA). In this paper, we investigated the involvement of two 
      chemosensory organs, the olfactory epithelium (OE) and the vomeronasal organ 
      (VNO), in olfactory preference and copulatory behavior in male rats. We found 
      that olfactory preferences were impaired by zinc sulfate lesion of the OE but not 
      surgical removal of the VNO. Copulatory behaviors, especially intromission 
      frequency and ejaculation, were also suppressed by zinc sulfate treatment. 
      Neuronal activation in the accessory olfactory bulb (AOB), the MeA, the CoA, and 
      the POA was analyzed after stimulation by airborne odors or soiled bedding of 
      estrous females using cFos immunohistochemistry. Although the OE and VNO belong 
      to different neural systems, the main and accessory olfactory systems, 
      respectively, both OE lesion and VNO removal almost equally suppressed the number 
      of cFos-immunoreactive cells in those areas that regulate olfactory preference. 
      These results suggest that signals received by the OE and VNO interact and 
      converge in the early stage of olfactory processing, in the AOB and its targets, 
      although they have distinct roles in the regulation of social behaviors.
CI  - Copyright (c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Dhungel, S
AU  - Dhungel S
AD  - Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo, Tokyo 
      113-8602, Japan.
FAU - Masaoka, M
AU  - Masaoka M
FAU - Rai, D
AU  - Rai D
FAU - Kondo, Y
AU  - Kondo Y
FAU - Sakuma, Y
AU  - Sakuma Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111001
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Amygdala/*cytology/*physiology
MH  - Animals
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Neurons/cytology/physiology
MH  - Olfactory Mucosa/*innervation/physiology
MH  - Olfactory Pathways/cytology/physiology
MH  - Olfactory Perception/physiology
MH  - Preoptic Area/cytology/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Sexual Behavior, Animal/physiology
MH  - Vomeronasal Organ/*innervation/physiology
EDAT- 2011/10/11 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/08/10 00:00 [received]
PHST- 2011/09/26 00:00 [revised]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - S0306-4522(11)01137-7 [pii]
AID - 10.1016/j.neuroscience.2011.09.051 [doi]
PST - ppublish
SO  - Neuroscience. 2011 Dec 29;199:225-34. doi: 10.1016/j.neuroscience.2011.09.051. 
      Epub 2011 Oct 1.