PMID- 21983376
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20221207
IS  - 1319-6138 (Print)
IS  - 1319-6138 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Oct
TI  - Use of antiplatelets. A survey of secondary prevention of ischemic stroke with 
      intracranial hemorrhage history in Chinese patients.
PG  - 335-9
AB  - OBJECTIVE: To explore whether antiplatelet (AP) agent therapy increased 
      intracranial hemorrhage (ICH) incidence and reduced ischemic stroke recurrence. 
      METHODS: A single-center retrospective cohort study involving 256 cases from 336 
      Chinese in-patients who had ischemic stroke with ICH history in Beijing Chaoyang 
      Hospital, Beijing, China between May 2005 and October 2009 was conducted. 
      Subjects were divided into 2 groups (with AP and without AP), followed by stroke 
      events for 12-38 months. Logistic regression analysis was used to evaluate the 
      effects of AP on cerebral infarction and ICH recurrence. RESULTS: The AP agent 
      did not increase ICH recurrence in the secondary prevention of ischemic stroke 
      with ICH history (odds ratio [OR] 1.431, confidence interval [CI] 0.198-2.467, 
      p=0.577). Hypertension and lobar hemorrhage were risk factors of ICH recurrence. 
      However, there was no statistical difference between recurrence of lobar 
      hemorrhage and AP use (x2=0.516, p=0.468). The AP agent significantly decreased 
      the incidence of cerebral infarction (OR 0.424, CI 0.190-0.950, p=0.037). 
      CONCLUSION: The AP agents may be beneficial to secondary prevention of ischemic 
      stroke with ICH history, with no increased incidence of cerebral hemorrhage. It 
      would be safer to maintain blood pressure in the normal range and to exclude 
      lobar hemorrhage when AP is used.
FAU - Jia, Weihua
AU  - Jia W
AD  - Department of Neurology, Capital Medical University, Beijing, China.
FAU - Zhou, Lichun
AU  - Zhou L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Saudi Arabia
TA  - Neurosciences (Riyadh)
JT  - Neurosciences (Riyadh, Saudi Arabia)
JID - 101252453
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Brain Ischemia/*drug therapy/ethnology/*prevention & control
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Female
MH  - Health Care Surveys/statistics & numerical data
MH  - Humans
MH  - Intracranial Hemorrhages/*chemically induced/*ethnology
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/*administration & dosage/adverse effects
MH  - Retrospective Studies
MH  - Secondary Prevention
EDAT- 2011/10/11 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
PST - ppublish
SO  - Neurosciences (Riyadh). 2011 Oct;16(4):335-9.