PMID- 21983724
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20111010
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 28
IP  - 5
DP  - 2011 Oct
TI  - [Identification of a novel HLA allele HLA-B*40:96].
PG  - 517-20
LID - 10.3760/cma.j.issn.1003-9406.2011.05.009 [doi]
AB  - OBJECTIVE: To identify a novel human leukocyte antigen (HLA) allele in Chinese 
      and investigate its inheritance in the family. METHODS: Exceptional reaction 
      pattern was detected in HLA-B locus in HLA typing using Luminex DNA polymerase 
      chain reaction with sequence specific oligonucleotide probe hybridization 
      (PCR-SSOP) assay. A confirmatory test for the novel HLA allele was performed by 
      DNA sequencing based typing of the proband's family. RESULTS: The DNA sequence 
      was confirmed to be a novel HLA B allele. There were 7 nucleotides which differed 
      from the closest matching HLA B*40:06:01 at positions 302(G to A), 309(G to C), 
      311(A to C), 313(C to G), 314(T to C), 317(G to T), and 319(G to C) in exon 2, 
      which resulted in 5 amino acid changes at codon 101 (Ser to Asn), 104 (Asn to 
      Thr), 105 (Leu to Ala), 106 (Arg to Leu), and 107 (Gly to Arg), respectively. 
      Family investigation indicated that the novel allele was transmitted from the 
      proband's father. CONCLUSION: A novel HLA B allele was identified and officially 
      named as HLA-B*40:96 (GenBank accession No. FJ374890) by the WHO Nomenclature 
      Committee for Factors of the HLA System.
FAU - Zhu, Chuan-fu
AU  - Zhu CF
AD  - Blood Center of Shandong Province, Jinan, Shandong, Peolple's Republic of China. 
      chuanfuzhu@yahoo.com.cn
FAU - Zhang, Yi
AU  - Zhang Y
FAU - Zhuang, Yun-long
AU  - Zhuang YL
FAU - Song, Yong-hong
AU  - Song YH
FAU - Liu, Yan
AU  - Liu Y
FAU - Nie, Xiang-min
AU  - Nie XM
LA  - chi
SI  - GENBANK/FJ374890
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - *Alleles
MH  - Base Sequence
MH  - Female
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Molecular Sequence Data
MH  - Pedigree
MH  - Sequence Alignment
EDAT- 2011/10/11 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 940628102 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2011.05.009 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Oct;28(5):517-20. doi: 
      10.3760/cma.j.issn.1003-9406.2011.05.009.