PMID- 21985845
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20220408
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 157
IP  - 2
DP  - 2012
TI  - Diagnostic value of the serum-specific IgE ratio of omega-5 gliadin to wheat in adult 
      patients with wheat-induced anaphylaxis.
PG  - 147-50
LID - 10.1159/000327549 [doi]
AB  - BACKGROUND: Wheat is an important food allergen associated with severe allergic 
      reactions, including wheat-dependent exercise-induced anaphylaxis (WDEIA) and 
      wheat-induced anaphylaxis (WIA). To diagnose WDEIA, an exercise challenge test 
      following wheat ingestion is performed, which is time-consuming and unsafe. The 
      compound omega-5 gliadin has been identified as a major allergen for WDEIA and WIA. 
      We evaluated the diagnostic value of serum immunoglobulin E (IgE) ratios of omega-5 
      gliadin to wheat in adult patients with WDEIA or WIA. METHODS: In total, 27 
      patients were enrolled and classified into 2 groups according to the severity of 
      their allergic reactions to wheat. Serum IgE, specific to wheat and omega-5 gliadin, 
      was measured using the ImmunoCAP system. To evaluate the diagnostic value, 
      receiver operator characteristic curves were produced. RESULTS: Group 1 included 
      17 patients with a history of anaphylaxis and group 2 included 10 patients having 
      urticaria or atopic dermatitis. Serum IgE specific to wheat was increased in 47% 
      of group 1 and 100% of group 2. However, all patients in group 1 had high serum 
      IgE specific to omega-5 gliadin, whereas only 20% of group 2 showed increased levels. 
      To identify a better diagnostic value, the log-transformed IgE ratio of omega-5 
      gliadin to wheat was calculated, with the cutoff value at 0.3. Based on these 
      criteria, we found 100% sensitivity and specificity. CONCLUSIONS: This study 
      confirms that the serum IgE ratio of omega-5 gliadin to wheat may be a useful marker 
      for the diagnosis of WDEIA and WIA.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Park, Han-Jung
AU  - Park HJ
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Kim, Joo-Hee
AU  - Kim JH
FAU - Kim, Jeong-Eun
AU  - Kim JE
FAU - Jin, Hyun-Jung
AU  - Jin HJ
FAU - Choi, Gil-Soon
AU  - Choi GS
FAU - Ye, Young-Min
AU  - Ye YM
FAU - Park, Hae-Sim
AU  - Park HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111005
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (omega-5 gliadin, wheat)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-90-3 (Gliadin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/*immunology
MH  - Anaphylaxis/*diagnosis/immunology
MH  - Antibody Specificity/*immunology
MH  - Antigens, Plant
MH  - Female
MH  - Gliadin/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Sensitivity and Specificity
MH  - Triticum/*immunology
MH  - Wheat Hypersensitivity/*diagnosis/immunology
MH  - Young Adult
EDAT- 2011/10/12 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/10/12 06:00
PHST- 2010/12/20 00:00 [received]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 000327549 [pii]
AID - 10.1159/000327549 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2012;157(2):147-50. doi: 10.1159/000327549. Epub 2011 
      Oct 5.