PMID- 21986137
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20170214
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Linking)
VI  - 39
IP  - 4
DP  - 2011
TI  - Effect of single-injection versus continuous local infiltration analgesia after 
      total knee arthroplasty: a randomized, double-blind, placebo-controlled study.
PG  - 1369-80
AB  - In this randomized, double-blind, placebo-controlled, single-centre study, 80 
      patients (American Society of Anesthesiologists physical status I-III) received 
      postoperative single-injection local infiltration analgesia (SLIA), continuous 
      local infiltration analgesia (CLIA) or placebo (control group). Intravenous 
      patient-controlled morphine was used as rescue analgesia. The CLIA group showed 
      lower postoperative visual analogue scale (VAS) pain scores from 8 to 48 h at 
      rest and from 16 to 48 h during activity compared with the SLIA group. The CLIA 
      group also had significantly lower consumption of morphine from 24 to 48 h 
      postoperatively versus the SLIA group. Patient satisfaction was higher, and 
      maximum flexion of the knee on postoperative days 7 and 90 was greater, in the 
      CLIA group compared with the SLIA group. CLIA provided prolonged superior 
      analgesia and was associated with more favourable functional recovery and patient 
      satisfaction compared with SLIA.
FAU - Zhang, S
AU  - Zhang S
AD  - Postgraduate Education College, Ningxia Medical University, Yinchuan, China.
FAU - Wang, F
AU  - Wang F
FAU - Lu, Z D
AU  - Lu ZD
FAU - Li, Y P
AU  - Li YP
FAU - Zhang, L
AU  - Zhang L
FAU - Jin, Q H
AU  - Jin QH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Analgesia, Patient-Controlled
MH  - Analgesics, Opioid/*administration & dosage
MH  - Anesthetics, Local/*administration & dosage
MH  - *Arthroplasty, Replacement, Knee
MH  - Case-Control Studies
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Morphine/*administration & dosage
MH  - Pain Management
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy/etiology
MH  - Postoperative Care
MH  - Prognosis
MH  - Recovery of Function
MH  - Young Adult
EDAT- 2011/10/12 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.1177/147323001103900423 [doi]
PST - ppublish
SO  - J Int Med Res. 2011;39(4):1369-80. doi: 10.1177/147323001103900423.