PMID- 21987237
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20161125
IS  - 1532-2114 (Electronic)
IS  - 1532-2114 (Linking)
VI  - 12
IP  - 12
DP  - 2011 Dec
TI  - Tissue Doppler imaging in the left ventricle and right ventricle in healthy 
      children: normal age-related peak systolic velocities, timings, and time 
      differences.
PG  - 953-60
LID - 10.1093/ejechocard/jer186 [doi]
AB  - AIMS: Tissue Doppler imaging (TDI) enables assessment of velocities and timings 
      within the left (LV) and the right (RV) ventricle with high temporal resolution. 
      Knowledge on normal age-related values of peak systolic velocities and timings in 
      healthy children may optimize the benefit of device-based therapies in paediatric 
      patients with heart failure. METHODS AND RESULTS: A total of 123 healthy children 
      (from 1 month to 18 years old) underwent TDI evaluation of the RV and LV. Peak 
      systolic velocity and time to peak systolic velocity were assessed at the basal 
      LV lateral wall, inter-ventricular septum (IVS), RV free wall (RVFW), and at the 
      RV outflow tract (RVOT). Intra-ventricular time differences were calculated. 
      Regression analysis was performed to assess the age dependency of the ventricular 
      mechanics. Median peak velocities were: LV lateral wall: 6.3 cm/s (inter-quartile 
      range (IQR): 5.1-7.9 cm/s); IVS: 6.0 cm/s (5.4-6.7 cm/s); RVFW: 10.2 cm/s 
      (8.9-11.3 cm/s); RVOT: 7.2 cm/s (6.0-8.2 cm/s). Timings of peak systolic 
      velocities were: LV lateral wall: 101 ms (91-112 ms); IVS: 114 ms (100-128 ms); 
      RVFW: 177 ms (157-194 ms); RVOT: 100 ms (88-113 ms). Timings and peak velocities 
      significantly increased with age at both ventricles. No relevant time difference 
      was observed within the LV, whereas a considerable time delay was observed within 
      the RV between the RVFW and the IVS (62 ms, IQR: 45-74 ms) and between the RVFW 
      and the RVOT (74 ms, IQR: 59-93 ms). CONCLUSION: The present evaluation provides 
      TDI-derived physiological values on normal LV and RV mechanics of healthy 
      children. Within the LV, no relevant time difference was observed, whereas a 
      considerable mechanical delay is observed within the healthy RV.
FAU - van der Hulst, Annelies E
AU  - van der Hulst AE
AD  - Division of Pediatric Cardiology, Department of Pediatrics, J6-S Leiden 
      University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The 
      Netherlands. a.e.van_der_hulst@lumc.nl
FAU - Delgado, Victoria
AU  - Delgado V
FAU - Ten Harkel, Arend D J
AU  - Ten Harkel AD
FAU - Klitsie, Liselotte M
AU  - Klitsie LM
FAU - Filippini, Luc H P M
AU  - Filippini LH
FAU - Bax, Jeroen J
AU  - Bax JJ
FAU - Blom, Nico A
AU  - Blom NA
FAU - Roest, Arno A W
AU  - Roest AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111010
PL  - England
TA  - Eur J Echocardiogr
JT  - European journal of echocardiography : the journal of the Working Group on 
      Echocardiography of the European Society of Cardiology
JID - 100890618
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Heart Ventricles/*diagnostic imaging
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Linear Models
MH  - Male
MH  - Pediatrics
MH  - Prospective Studies
MH  - Reference Values
MH  - Systole
MH  - Time Factors
MH  - Ultrasonography, Doppler/*methods
EDAT- 2011/10/12 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - jer186 [pii]
AID - 10.1093/ejechocard/jer186 [doi]
PST - ppublish
SO  - Eur J Echocardiogr. 2011 Dec;12(12):953-60. doi: 10.1093/ejechocard/jer186. Epub 
      2011 Oct 10.