PMID- 2198731
OWN - NLM
STAT- MEDLINE
DCOM- 19900905
LR  - 20131121
IS  - 0300-5860 (Print)
IS  - 0300-5860 (Linking)
VI  - 79
IP  - 6
DP  - 1990 Jun
TI  - [Comparison of enalapril and captopril in the treatment of chronic heart 
      failure].
PG  - 429-35
AB  - The long-term effect of enalapril (group 1) and captopril (group 2) on clinical 
      symptomatology and left ventricular function was evaluated in 29 patients with 
      severe congestive heart failure (13 ischemic and 12 dilated cardiomyopathy, four 
      valvular heart disease). During the 6-month observation period, five patients 
      died (two on enalapril and three on captopril therapy = 6-month mortality rate 
      18%). Nine patients showed no beneficial effect of enalapril or captopril on 
      clinical and hemodynamic findings (= nonresponders). The initial findings on 
      these nine patients were, however, not significantly different from the clinical 
      and hemodynamic findings on the patients who improved. Enalapril had to be 
      discontinued in two patients because of side effects (progressive renal failure 
      and gastrointestinal symptoms, respectively). A total of 22 patients completed 
      the study, 11 treated with enalapril (mean dosage 25 +/- 10 mg/day) and 11 
      treated with captopril (mean dosage 77 +/- 26 mg/day). After 6 months there was a 
      significant improvement according to the New York Heart Association (NYHA) 
      classification, from 2.4 to 1.9 in group 1 (p less than 0.01) and from 2.7 to 1.9 
      in group 2 (p less than 0.001). The cardio-thoracic ratio (chest x-ray) decreased 
      significantly from 0.59 to 0.56 (p less than 0.001) in group 1 and from 0.56 to 
      0.53 (p less than 0.001) in group 2. Physical working capacity (bicycle 
      ergometry) showed a significant increase in both groups from 61% to 81% in group 
      1 (p less than 0.01) and from 66% to 83% in group 2 (p less than 0.01).(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Tjon-A-Meeuw, L
AU  - Tjon-A-Meeuw L
AD  - Departement fur Innere Medizin, Universitatsspital, Zurich.
FAU - Hess, O M
AU  - Hess OM
FAU - Greminger, P
AU  - Greminger P
FAU - Maire, R
AU  - Maire R
FAU - Jenni, R
AU  - Jenni R
FAU - Krayenbuehl, H P
AU  - Krayenbuehl HP
LA  - ger
PT  - Clinical Trial
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Vergleich von Enalapril und Captopril in der Behandlung der chronischen 
      Herzinsuffizienz.
PL  - Germany
TA  - Z Kardiol
JT  - Zeitschrift fur Kardiologie
JID - 0360430
RN  - 69PN84IO1A (Enalapril)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Blood Pressure/drug effects
MH  - Captopril/*therapeutic use
MH  - Cardiac Output/drug effects
MH  - Cardiomyopathy, Dilated/drug therapy
MH  - Coronary Disease/drug therapy
MH  - Enalapril/*therapeutic use
MH  - Female
MH  - Heart Failure/*drug therapy
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
PST - ppublish
SO  - Z Kardiol. 1990 Jun;79(6):429-35.