PMID- 21988224
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20211020
IS  - 1365-2125 (Electronic)
IS  - 0306-5251 (Print)
IS  - 0306-5251 (Linking)
VI  - 73
IP  - 3
DP  - 2012 Mar
TI  - Is a positive history of non-anaesthetic drug allergy a predictive factor for 
      positive allergy tests to anaesthetics?
PG  - 460-6
LID - 10.1111/j.1365-2125.2011.04112.x [doi]
AB  - AIMS: International recommendations stipulate not performing screening skin tests 
      to a drug in the absence of a clinical history consistent with that specific drug 
      allergy. Nevertheless, two publications showed that a positive history of 
      non-anaesthetic drug allergy was the only predictive factor for a positive skin 
      test when screening for allergy to anaesthetic drugs was done. We selected from a 
      surgical population 40 volunteers with a prior history of allergy to 
      non-anaesthetic drugs in order to analyse the prevalence of positive allergy 
      tests to anaesthetics. METHODS: The selected adult patients were tested for 11 
      anaesthetic drugs using in vivo tests: skin prick (SPT) and intradermal (IDT) 
      tests and in vitro tests: the basophil activation test (BAT) and detection of 
      drug-specific immunoglobulin E (IgE). RESULTS: The prevalence for the positive 
      SPT and IDT was 1.6% and 5.8% respectively. The result of flow cytometry agreed 
      with the SPT in five out of seven positive SPT (71%). IgEs confirmed two positive 
      SPT with corresponding positive BAT. Ten per cent of the patients had a positive 
      prick test to neuromuscular blocking agents (NMBA). For midazolam none of the SPT 
      was positive, but 11 patients had positive IDT nonconfirmed by BAT. CONCLUSION: 
      The prevalence of positive in vivo and in vitro allergy tests to NMBAs is higher 
      in our study population. This could be an argument for pre-operative SPT to NMBAs 
      for the surgical population with reported non-anaesthetic drug allergies. A 
      larger prospective study is needed to validate changes in clinical practice.
CI  - (c) 2011 The Authors. British Journal of Clinical Pharmacology (c) 2011 The British 
      Pharmacological Society.
FAU - Hagau, Natalia
AU  - Hagau N
AD  - Department of Anaesthesia and Intensive Care, University of Medicine and Pharmacy 
      'Iuliu Hatieganu' Cluj-Napoca, Romania. hagaunatalia@gmail.com
FAU - Gherman-Ionica, Nadia
AU  - Gherman-Ionica N
FAU - Hagau, Denisa
AU  - Hagau D
FAU - Tranca, Sebastian
AU  - Tranca S
FAU - Sfichi, Manuela
AU  - Sfichi M
FAU - Longrois, Dan
AU  - Longrois D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Clin Pharmacol
JT  - British journal of clinical pharmacology
JID - 7503323
RN  - 0 (Allergens)
RN  - 0 (Anesthetics)
RN  - 0 (Neuromuscular Blocking Agents)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allergens/*immunology
MH  - Anesthetics/*immunology
MH  - Basophil Degranulation Test/methods/standards
MH  - Drug Hypersensitivity/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Intradermal Tests
MH  - Male
MH  - Middle Aged
MH  - Neuromuscular Blocking Agents/adverse effects/*immunology
MH  - Predictive Value of Tests
MH  - Skin Tests/methods
MH  - Young Adult
PMC - PMC3370351
EDAT- 2011/10/13 06:00
MHDA- 2012/06/13 06:00
PMCR- 2013/03/01
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2125.2011.04112.x [doi]
PST - ppublish
SO  - Br J Clin Pharmacol. 2012 Mar;73(3):460-6. doi: 10.1111/j.1365-2125.2011.04112.x.