PMID- 21988460
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20120214
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 75
IP  - 3
DP  - 2012 Mar
TI  - Selective increase in blood dendritic cell antigen-3-positive dendritic cells in 
      bronchoalveolar lavage fluid in allergic patients.
PG  - 305-13
LID - 10.1111/j.1365-3083.2011.02649.x [doi]
AB  - Dendritic cells (DCs) are specific antigen-presenting cells that play critical 
      roles in the initiation and polarization of immune responses. DCs residing in the 
      lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed 
      DC compartment in the peripheral blood and BALF of patients with allergy and in 
      controls. Plasmacytoid and four distinct subsets of myeloid DCs [characterized by 
      the expression of blood dendritic cell antigen (BDCA)-1+ and -3+ and CD16 
      positivity or negativity] were detected in both tested compartments. We further 
      evaluated the expression of C-type lectins [mannose receptor (MR), dendritic 
      cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) 
      and dendritic and epithelial cells (DEC)-205] relevant to the pathogenesis of 
      asthma. Interestingly, we found a selective increase in the frequency of myeloid 
      DC-expressing BDCA-3 and MR particularly in BALF from allergic patients. Specific 
      and highly statistically significant increase in BDCA-3+ and/or MR+ DCs brings a 
      novel characteristic to BAL analysis in allergic patients.
CI  - (c) 2011 The Authors. Scandinavian Journal of Immunology (c) 2011 Blackwell 
      Publishing Ltd.
FAU - Kayserova, J
AU  - Kayserova J
AD  - Department of Immunology, Second Faculty of Medicine, Charles University and 
      University Hospital Motol, Prague, Czech Republic.
FAU - Zentsova-Jaresova, I
AU  - Zentsova-Jaresova I
FAU - Budinsky, V
AU  - Budinsky V
FAU - Rozkova, D
AU  - Rozkova D
FAU - Kopecka, J
AU  - Kopecka J
FAU - Vernerova, E
AU  - Vernerova E
FAU - Pohunek, P
AU  - Pohunek P
FAU - Skalicka, V
AU  - Skalicka V
FAU - Spisek, R
AU  - Spisek R
FAU - Sediva, A
AU  - Sediva A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (FCGR3B protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Adult
MH  - Asthma/blood/*immunology
MH  - Bronchoalveolar Lavage Fluid/cytology/*immunology
MH  - Cell Adhesion Molecules/blood/*immunology
MH  - Child
MH  - Dendritic Cells/cytology/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - GPI-Linked Proteins/blood/immunology
MH  - Humans
MH  - Immunophenotyping/methods
MH  - Lectins, C-Type/blood/*immunology
MH  - Lung/cytology/immunology
MH  - Male
MH  - Receptors, Cell Surface/blood/*immunology
MH  - Receptors, IgG/blood/immunology
MH  - Statistics, Nonparametric
EDAT- 2011/10/13 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1111/j.1365-3083.2011.02649.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2012 Mar;75(3):305-13. doi: 10.1111/j.1365-3083.2011.02649.x.