PMID- 21988721
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 5
DP  - 2011 Nov
TI  - Race-specific type 1 diabetes risk of HLA-DR7 haplotypes.
PG  - 348-51
LID - 10.1111/j.1399-0039.2011.01772.x [doi]
AB  - The aim of this study was to test the hypothesis that closely related human 
      leukocyte antigen (HLA) haplotypes containing the DRB1*07:01 gene ['DR7' 
      (DRB1*07:01-DQA1*02:01-DQB1*02:01g or DRB1*07:01-DQA1*03:01-DQB1*02:01g) 
      haplotypes] derived from European and African populations differ in their genetic 
      susceptibility for type 1 diabetes (T1D) depending on the DQ-alpha molecule present. 
      A combined total of 98 African American T1D patients from the Type 1 Diabetes 
      Genetics Consortium and from Children's Hospital and Research Center Oakland were 
      genotyped for the HLA class II loci DRB1, DQA1, and DQB1. DNA samples extracted 
      from newborn blood spot cards from African Americans born in California (n = 947) 
      were used as a population-based control group. Among African American cases, the 
      European-derived DRB1*07:01-DQA1*02:01-DQB1*02:01g haplotype was protective for 
      T1D risk (odds ratio (OR) = 0.34; 95% confidence interval (CI) 0.14-0.78; P < 
      0.011), but the African-derived DRB1*07:01-DQA1*03:01-DQB1*02:01g haplotype 
      increased T1D risk (OR = 3.96; 95% CI 1.94-8.08; P < 5.5E-05). The effect of 
      DRB1*07:01-DQB1*02:01g on T1D susceptibility depends on the DQA1 allele. 
      DRB1*07:01-DQA1*02:01-DQB1*02:01g is protective for T1D; however, the presence of 
      DQA1*03:01 on the DRB1*07:01-DQB1*02:01g haplotype not only renders the DR7 
      haplotype not protective but also creates a haplotype with significant T1D risk. 
      These data underscore the importance of assessing genetic effects within ethnic 
      context.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Noble, J A
AU  - Noble JA
AD  - Children's Hospital Oakland Research Institute, Oakland, CA, USA. 
      jnoble@chori.org
FAU - Johnson, J
AU  - Johnson J
FAU - Lane, J A
AU  - Lane JA
FAU - Valdes, A M
AU  - Valdes AM
LA  - eng
GR  - R01 DK61722/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - U01 DK062418/DK/NIDDK NIH HHS/United States
GR  - R01 DK061722-08/DK/NIDDK NIH HHS/United States
GR  - UL1RR024131-01/RR/NCRR NIH HHS/United States
GR  - U01 DK062418-06/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024131-01/RR/NCRR NIH HHS/United States
GR  - R01 DK061722/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR7 Antigen)
SB  - IM
MH  - Adolescent
MH  - Black People/ethnology/*genetics
MH  - Child
MH  - Diabetes Mellitus, Type 1/*genetics/immunology
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DR7 Antigen/*genetics/immunology
MH  - *Haplotypes
MH  - Humans
MH  - Male
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3193161
MID - NIHMS322263
EDAT- 2011/10/13 06:00
MHDA- 2012/05/30 06:00
PMCR- 2012/11/01
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - 10.1111/j.1399-0039.2011.01772.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Nov;78(5):348-51. doi: 10.1111/j.1399-0039.2011.01772.x.