PMID- 21988723
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 5
DP  - 2011 Nov
TI  - Genetic variation and hitchhiking between structurally polymorphic Alu insertions 
      and HLA-A, -B, and -C alleles and other retroelements within the MHC class I 
      region.
PG  - 359-77
LID - 10.1111/j.1399-0039.2011.01776.x [doi]
AB  - We investigated structurally polymorphic Alu insertions (POALINs) at five loci in 
      the major histocompatibility complex (MHC) class I genomic region to determine 
      their allele and haplotype frequencies and associations with the human leukocyte 
      antigen (HLA)-A, -B, and -C genes in three populations, the Australian 
      Caucasians, Japanese, and African Americans. The POALINs varied in allelic 
      frequency between 0% and 42.3% with significant differences between populations 
      at three of the five loci. The linkage disequilibrium (LD) between Alu insertions 
      and the HLA-A, -B, or -C alleles and previously published polymorphic 
      retroelements (four SVA and human endogenous retrovirus type 9 (HERVK9) loci) 
      within the class I region of the MHC were calculated in pairwise analyses of 
      haplotypes to show strong allelic associations and possible crossing-over events 
      between some loci. Each POALIN was in significant LD with a variety of HLA-A, -B, 
      or -C two-digit alleles probably as a result of hitchhiking. The POALINs helped 
      to further stratify the HLA-A:B:C haplotypes into different POALIN:HLA-A:B:C 
      haplotype frequencies. Of the multilocus haplotype analyses, the seven- and 
      eight-locus haplotypes showed the largest number of differences between the 
      populations, and fewer matched haplotypes between populations that ranged, for 
      example, from 49% for HLA-B:HLA-A haplotypes to 7% for 
      AluMICB:HLA-B:HLA-C:AluTF:AluHJ:HLA-A:AluHG:AluTF haplotypes in the Japanese. 
      This comparative study of multilocus POALINs in the HLA class I region of three 
      ethnic populations shows that POALINs alone or together with the HLA class I 
      alleles and other retroelements are informative ancestral markers for assessing 
      the interrelationship of HLA class I haplotype lineages, LD, and genetic 
      diversity within the same and/or different populations.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Kulski, J K
AU  - Kulski JK
AD  - Centre for Forensic Science, The University of Western Australia, Nedlands, WA 
      6008, Australia. kulski@me.com
FAU - Shigenari, A
AU  - Shigenari A
FAU - Inoko, H
AU  - Inoko H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - *Alu Elements
MH  - Asian People/genetics
MH  - Ethnicity/genetics
MH  - *Genes, MHC Class I
MH  - *Genetic Variation
MH  - Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/chemistry/*genetics
MH  - HLA-B Antigens/chemistry/*genetics
MH  - HLA-C Antigens/chemistry/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/chemistry/*genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Polymorphism, Genetic
MH  - White People/genetics
EDAT- 2011/10/13 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01776.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Nov;78(5):359-77. doi: 10.1111/j.1399-0039.2011.01776.x.