PMID- 21989871 OWN - NLM STAT- MEDLINE DCOM- 20120222 LR - 20161125 IS - 1525-8955 (Electronic) IS - 0885-3010 (Linking) VI - 58 IP - 10 DP - 2011 Oct TI - Image reconstruction in intravascular photoacoustic imaging. PG - 2067-77 LID - 10.1109/TUFFC.2011.2057 [doi] AB - Intravascular photoacoustic (IVPA) imaging is a technique for visualizing atherosclerotic plaques with differential composition. Unlike conventional photoacoustic tomography scanning, where the scanning device rotates around the subject, the scanning aperture in IVPA imaging is enclosed within the imaged object. The display of the intravascular structure is typically obtained by converting detected photoacoustic waves into Cartesian coordinates, which can produce images with severe artifacts. Because the acquired data are highly limited, there does not exist a stable reconstruction algorithm for such imaging geometry. The purpose of this work was to apply image reconstruction concepts to explore the feasibility and efficacy of image reconstruction algorithms in IVPA imaging using traditional analytical formulas, such as a filtered back-projection (FBP) and the lambda-tomography method. Although the closed-form formulas are not exact for the IVPA system, a general picture of and interface information about objects are provided. To improve the quality of the reconstructed image, the iterative expectation maximization and penalized least-squares methods were adopted to minimize the difference between the measured signals and those generated by a reconstructed image. In this work, we considered both the ideal point detector and the acoustic transducers with finite- size aperture. The transducer effects including the spatial response of aperture and acoustoelectrical impulse responses were incorporated in the system matrix to reduce the aroused distortion in the IVPA reconstruction. Computer simulations and experiments were carried out to validate the methods. The applicability and the limitation of the reconstruction method were also discussed. FAU - Sheu, Yae-lin AU - Sheu YL AD - Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan. FAU - Chou, Cheng-Ying AU - Chou CY FAU - Hsieh, Bao-Yu AU - Hsieh BY FAU - Li, Pai-Chi AU - Li PC LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - IEEE Trans Ultrason Ferroelectr Freq Control JT - IEEE transactions on ultrasonics, ferroelectrics, and frequency control JID - 9882735 SB - IM MH - Algorithms MH - Artifacts MH - Computer Simulation MH - Hair/chemistry/diagnostic imaging MH - Humans MH - Image Processing, Computer-Assisted/*methods MH - Least-Squares Analysis MH - Models, Biological MH - Phantoms, Imaging MH - Photoacoustic Techniques/instrumentation/*methods MH - Reproducibility of Results MH - Signal Processing, Computer-Assisted MH - Transducers MH - Ultrasonography, Interventional/*instrumentation EDAT- 2011/10/13 06:00 MHDA- 2012/02/23 06:00 CRDT- 2011/10/13 06:00 PHST- 2011/10/13 06:00 [entrez] PHST- 2011/10/13 06:00 [pubmed] PHST- 2012/02/23 06:00 [medline] AID - 10.1109/TUFFC.2011.2057 [doi] PST - ppublish SO - IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Oct;58(10):2067-77. doi: 10.1109/TUFFC.2011.2057.