PMID- 21990949
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20211020
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 17
IP  - 32
DP  - 2011 Aug 28
TI  - Future of liver transplantation: non-human primates for patient-specific organs 
      from induced pluripotent stem cells.
PG  - 3684-90
LID - 10.3748/wjg.v17.i32.3684 [doi]
AB  - Strategies to fill the huge gap in supply versus demand of human organs include 
      bioartificial organs, growing humanized organs in animals, cell therapy, and 
      implantable bioengineered constructs. Reproducing the complex relations between 
      different cell types, generation of adequate vasculature, and immunological 
      complications are road blocks in generation of bioengineered organs, while 
      immunological complications limit the use of humanized organs produced in 
      animals. Recent developments in induced pluripotent stem cell (iPSC) biology 
      offer a possibility of generating human, patient-specific organs in non-human 
      primates (NHP) using patient-derived iPSC and NHP-derived iPSC lacking the 
      critical developmental genes for the organ of interest complementing a NHP 
      tetraploid embryo. The organ derived in this way will have the same human 
      leukocyte antigen (HLA) profile as the patient. This approach can be curative in 
      genetic disorders as this offers the possibility of gene manipulation and 
      correction of the patient's genome at the iPSC stage before tetraploid 
      complementation. The process of generation of patient-specific organs such as the 
      liver in this way has the great advantage of making use of the natural signaling 
      cascades in the natural milieu probably resulting in organs of great quality for 
      transplantation. However, the inexorable scientific developments in this 
      direction involve several social issues and hence we need to educate and prepare 
      society in advance to accept the revolutionary consequences, good, bad and ugly.
FAU - Sanal, Madhusudana Girija
AU  - Sanal MG
AD  - Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110070, 
      India. sanalmg@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Animals
MH  - *Cell Differentiation
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology
MH  - Liver Diseases/surgery
MH  - Liver Transplantation/*methods
MH  - Organ Culture Techniques/ethics/methods
MH  - Pan troglodytes
MH  - *Primates
MH  - Tissue Engineering/*methods
PMC - PMC3181453
OTO - NOTNLM
OT  - Anencephaly
OT  - Chimpanzee
OT  - Fumaryl acetoacetate hydrolase deficient
OT  - Hepatocytes
OT  - Hhex
OT  - Induced pluripotent stem cells
OT  - Non-human primates
OT  - Tetraploid
EDAT- 2011/10/13 06:00
MHDA- 2012/01/18 06:00
PMCR- 2011/08/28
CRDT- 2011/10/13 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/04/20 00:00 [revised]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
PHST- 2011/08/28 00:00 [pmc-release]
AID - 10.3748/wjg.v17.i32.3684 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2011 Aug 28;17(32):3684-90. doi: 10.3748/wjg.v17.i32.3684.