PMID- 21993073
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20161020
IS  - 1578-1283 (Electronic)
IS  - 0213-9111 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Jan-Feb
TI  - [The efficiency of drug prescription: impact of a therapeutic exchange program].
PG  - 58-64
LID - 10.1016/j.gaceta.2011.06.009 [doi]
AB  - OBJECTIVE: To assess the impact of substituting proton pump inhibitors (PPI) for 
      omeprazole. METHOD: We performed a community trial of the impact of a therapeutic 
      exchange program in the primary care teams of a region compared with 
      non-implementation in a control region. The study included patients prescribed a 
      PPI between May 2008 and June 2009. The intervention consisted of providing 
      educational sessions to physicians (n=68), as well as a list of patients 
      receiving a PPI who were suitable for therapeutic exchange. Information was 
      gathered from medical records (PPI prescribed, primary care team) and the 
      pharmacy database (cost of defined daily doses of the PPI). The percentage of 
      therapeutic exchange in each region before and after the intervention was 
      compared through relative risk (RR). The percentage of omeprazole at the end of 
      each study period and changes in PPI costs were also calculated. RESULTS: 
      Therapeutic exchange was higher in the intervention group (RR: 4.2; 95%CI: 
      3.1-5.8) than in the control group (RR: 1.8; 95%CI: 1.2-2.6). The percentage of 
      patients prescribed omeprazole increased from 86.2% to 89.3% in the intervention 
      region and from 84.3% to 84.7% in the control region. The total cost of the PPI 
      group decreased by 7.6% in the intervention region and increased by 2.0% in the 
      control group. CONCLUSIONS: This study demonstrates the effectiveness of the 
      therapeutic exchange program. This is a simple intervention that is able to 
      modify prescription and reduce its costs.
CI  - Copyright A(c) 2011 SESPAS. Published by Elsevier Espana. All rights reserved.
FAU - Rosich, Isabel
AU  - Rosich I
AD  - Servicio de Atencion Primaria Alt Penedes-Garraf, Insituto Catalan de la Salud, 
      Vilanova i la Geltru, Barcelona, Espana. irosich.cp.ics@gencat.cat
FAU - Allepuz, Alejandro
AU  - Allepuz A
FAU - Alba, Gloria
AU  - Alba G
FAU - Benages, Nuria
AU  - Benages N
FAU - Arranz, Teresa
AU  - Arranz T
LA  - spa
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Eficiencia en la prescripcion de medicamentos: impacto de un programa de 
      intercambio terapeutico.
DEP - 20111011
PL  - Spain
TA  - Gac Sanit
JT  - Gaceta sanitaria
JID - 8901623
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Drug Substitution/*standards
MH  - Enzyme Inhibitors/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/*therapeutic use
MH  - Program Evaluation
MH  - Proton Pump Inhibitors/*therapeutic use
EDAT- 2011/10/14 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/01/24 00:00 [received]
PHST- 2011/06/08 00:00 [revised]
PHST- 2011/06/15 00:00 [accepted]
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - S0213-9111(11)00245-7 [pii]
AID - 10.1016/j.gaceta.2011.06.009 [doi]
PST - ppublish
SO  - Gac Sanit. 2012 Jan-Feb;26(1):58-64. doi: 10.1016/j.gaceta.2011.06.009. Epub 2011 
      Oct 11.