PMID- 21993877
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 220
IP  - 3
DP  - 2012 Apr
TI  - Effects of exposure to amphetamine derivatives on passive avoidance performance 
      and the central levels of monoamines and their metabolites in mice: correlations 
      between behavior and neurochemistry.
PG  - 495-508
LID - 10.1007/s00213-011-2504-0 [doi]
AB  - RATIONALE: Considerable evidence indicates that amphetamine derivatives can 
      deplete brain monoaminergic neurotransmitters. However, the behavioral and 
      cognitive consequences of neurochemical depletions induced by amphetamines are 
      not well established. OBJECTIVES: In this study, mice were exposed to dosing 
      regimens of 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine (METH), or 
      parachloroamphetamine (PCA) known to deplete the monoamine neurotransmitters 
      dopamine and serotonin, and the effects of these dosing regimens on learning and 
      memory were assessed. METHODS: In the same animals, we determined deficits in 
      learning and memory via passive avoidance (PA) behavior and changes in tissue 
      content of monoamine neurotransmitters and their primary metabolites in the 
      striatum, frontal cortex, cingulate, hippocampus, and amygdala via ex vivo 
      high-pressure liquid chromatography. RESULTS: Exposure to METH and PCA impaired 
      PA performance and resulted in significant depletions of dopamine, serotonin, and 
      their metabolites in several brain regions. Multiple linear regression analysis 
      revealed that the tissue concentration of dopamine in the anterior striatum was 
      the strongest predictor of PA performance, with an additional significant 
      contribution by the tissue concentration of the serotonin metabolite 
      5-hydroxyindoleacetic acid in the cingulate. In contrast to the effects of METH 
      and PCA, exposure to MDMA did not deplete anterior striatal dopamine levels or 
      cingulate levels of 5-hydroxyindoleacetic acid, and it did not impair PA 
      performance. CONCLUSIONS: These studies demonstrate that certain amphetamines 
      impair PA performance in mice and that these impairments may be attributable to 
      specific neurochemical depletions.
FAU - Murnane, Kevin Sean
AU  - Murnane KS
AD  - Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate 
      Research Center, Yerkes Imaging Center, 954 Gatewood Road, Atlanta, GA 
      30322-4250, USA. acmurna@emory.edu
FAU - Perrine, Shane Alan
AU  - Perrine SA
FAU - Finton, Brendan James
AU  - Finton BJ
FAU - Galloway, Matthew Peter
AU  - Galloway MP
FAU - Howell, Leonard Lee
AU  - Howell LL
FAU - Fantegrossi, William Edward
AU  - Fantegrossi WE
LA  - eng
GR  - K02 DA000517/DA/NIDA NIH HHS/United States
GR  - Z01 DA000517/ImNIH/Intramural NIH HHS/United States
GR  - R01 DA016736/DA/NIDA NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - K05 DA031246/DA/NIDA NIH HHS/United States
GR  - K02 DA000517-10/DA/NIDA NIH HHS/United States
GR  - DA020645/DA/NIDA NIH HHS/United States
GR  - DA024760/DA/NIDA NIH HHS/United States
GR  - K01 DA024760/DA/NIDA NIH HHS/United States
GR  - RR00165/RR/NCRR NIH HHS/United States
GR  - DA000517/DA/NIDA NIH HHS/United States
GR  - R21 DA020645/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111013
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Adrenergic Agents)
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 64-12-0 (p-Chloroamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adrenergic Agents/administration & dosage/toxicity
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Behavior, Animal/drug effects
MH  - Brain/drug effects/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Linear Models
MH  - Male
MH  - Memory/drug effects
MH  - Methamphetamine/administration & dosage/*toxicity
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Serotonin/metabolism
MH  - Serotonin Agents/administration & dosage/toxicity
MH  - p-Chloroamphetamine/administration & dosage/*toxicity
PMC - PMC3289749
MID - NIHMS339963
EDAT- 2011/10/14 06:00
MHDA- 2012/07/12 06:00
PMCR- 2012/04/01
CRDT- 2011/10/14 06:00
PHST- 2010/12/15 00:00 [received]
PHST- 2011/09/07 00:00 [accepted]
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - 10.1007/s00213-011-2504-0 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2012 Apr;220(3):495-508. doi: 
      10.1007/s00213-011-2504-0. Epub 2011 Oct 13.