PMID- 21994147
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20151119
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 121
IP  - 11
DP  - 2011 Nov
TI  - Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot 
      study.
PG  - 2468-72
LID - 10.1002/lary.22176 [doi]
AB  - OBJECTIVES/HYPOTHESIS: To determine the tolerability of xylitol mixed with water 
      as a nasal irrigant and to evaluate whether xylitol nasal irrigation results in 
      symptomatic improvement of subjects with chronic rhinosinusitis. STUDY DESIGN: A 
      prospective, randomized, double-blinded, controlled crossover pilot study. 
      METHODS: Twenty subjects were instructed to perform sequential 10-day courses of 
      daily xylitol and saline irrigations in a randomized fashion, with a 3-day 
      washout irrigation rest period at the start of each treatment arm. Collected data 
      included patient characteristics, along with Sino-Nasal Outcome Test 20 (SNOT-20) 
      and Visual Analog Scale (VAS) scores reported at the beginning and end of each 
      irrigation course. RESULTS: Fifteen of the 20 subjects (75%) returned their 
      SNOT-20 and VAS data for analysis. There was a significant reduction in SNOT-20 
      score during the xylitol phase of irrigation (mean drop of 2.43 points) as 
      compared to the saline phase (mean increase of 3.93 points), indicating improved 
      sinonasal symptoms (P = .0437). There was no difference in VAS scores. No patient 
      stopped performing the irrigations owing to intolerance of the xylitol, although 
      its sweet taste was not preferred by three subjects (21%). One patient reported 
      transient stinging with xylitol. CONCLUSIONS: Xylitol in water is a 
      well-tolerated agent for sinonasal irrigation. In the short term, xylitol 
      irrigations result in greater improvement of symptoms of chronic rhinosinusitis 
      as compared to saline irrigation.
CI  - Copyright (c) 2011 The American Laryngological, Rhinological, and Otological 
      Society, Inc.
FAU - Weissman, Joshua D
AU  - Weissman JD
AD  - Department of Otolaryngology-Head and Neck Surgery, Stanford Hospital and 
      Clinics, Stanford, California, USA.
FAU - Fernandez, Francisca
AU  - Fernandez F
FAU - Hwang, Peter H
AU  - Hwang PH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111012
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 451W47IQ8X (Sodium Chloride)
RN  - VCQ006KQ1E (Xylitol)
SB  - IM
EIN - Laryngoscope. 2012 Nov;122(11):2611
MH  - Adult
MH  - Chronic Disease
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Lavage/*methods
MH  - Pain Measurement
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Rhinitis/*therapy
MH  - Sinusitis/*therapy
MH  - Sodium Chloride/administration & dosage
MH  - Surveys and Questionnaires
MH  - Xylitol/*administration & dosage
EDAT- 2011/10/14 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/05/01 00:00 [revised]
PHST- 2011/05/04 00:00 [accepted]
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1002/lary.22176 [doi]
PST - ppublish
SO  - Laryngoscope. 2011 Nov;121(11):2468-72. doi: 10.1002/lary.22176. Epub 2011 Oct 
      12.