PMID- 21994368
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 31
IP  - 41
DP  - 2011 Oct 12
TI  - Transient suppression of broadband gamma power in the default-mode network is 
      correlated with task complexity and subject performance.
PG  - 14521-30
LID - 10.1523/JNEUROSCI.2483-11.2011 [doi]
AB  - Task performance is associated with increased brain metabolism but also with 
      prominent deactivation in specific brain structures known as the default-mode 
      network (DMN). The role of DMN deactivation remains enigmatic in part because its 
      electrophysiological correlates, temporal dynamics, and link to behavior are 
      poorly understood. Using extensive depth electrode recordings in humans, we 
      provide first electrophysiological evidence for a direct correlation between the 
      dynamics of power decreases in the DMN and individual subject behavior. We found 
      that all DMN areas displayed transient suppressions of broadband gamma (60-140 
      Hz) power during performance of a visual search task and, critically, we show for 
      the first time that the millisecond range duration and extent of the transient 
      gamma suppressions are correlated with task complexity and subject performance. 
      In addition, trial-by-trial correlations revealed that spatially distributed 
      gamma power increases and decreases formed distinct anticorrelated large-scale 
      networks. Beyond unraveling the electrophysiological basis of DMN dynamics, our 
      results suggest that, rather than indicating a mere switch to a global 
      exteroceptive mode, DMN deactivation encodes the extent and efficiency of our 
      engagement with the external world. Furthermore, our findings reveal a pivotal 
      role for broadband gamma modulations in the interplay between task-positive and 
      task-negative networks mediating efficient goal-directed behavior and facilitate 
      our understanding of the relationship between electrophysiology and neuroimaging 
      studies of intrinsic brain networks.
FAU - Ossandon, Tomas
AU  - Ossandon T
AD  - Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR5292, Brain Dynamics and 
      Cognition Team, F-69500 Lyon-Bron, France.
FAU - Jerbi, Karim
AU  - Jerbi K
FAU - Vidal, Juan R
AU  - Vidal JR
FAU - Bayle, Dimitri J
AU  - Bayle DJ
FAU - Henaff, Marie-Anne
AU  - Henaff MA
FAU - Jung, Julien
AU  - Jung J
FAU - Minotti, Lorella
AU  - Minotti L
FAU - Bertrand, Olivier
AU  - Bertrand O
FAU - Kahane, Philippe
AU  - Kahane P
FAU - Lachaux, Jean-Philippe
AU  - Lachaux JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiopathology
MH  - *Brain Mapping
MH  - Brain Waves/*physiology
MH  - Computer Simulation
MH  - Electroencephalography
MH  - Epilepsy/pathology/physiopathology
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Middle Aged
MH  - *Models, Neurological
MH  - Neural Pathways/physiopathology
MH  - Neuropsychological Tests
MH  - Nonlinear Dynamics
MH  - Photic Stimulation/methods
MH  - Reaction Time/physiology
MH  - Statistics as Topic
MH  - Time Factors
MH  - Young Adult
PMC - PMC6703400
EDAT- 2011/10/14 06:00
MHDA- 2011/12/13 00:00
PMCR- 2012/04/12
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2012/04/12 00:00 [pmc-release]
AID - 31/41/14521 [pii]
AID - 3727860 [pii]
AID - 10.1523/JNEUROSCI.2483-11.2011 [doi]
PST - ppublish
SO  - J Neurosci. 2011 Oct 12;31(41):14521-30. doi: 10.1523/JNEUROSCI.2483-11.2011.