PMID- 21994486
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1662-453X (Electronic)
IS  - 1662-4548 (Print)
IS  - 1662-453X (Linking)
VI  - 5
DP  - 2011
TI  - Newborn interneurons in the accessory olfactory bulb promote mate recognition in 
      female mice.
PG  - 113
LID - 10.3389/fnins.2011.00113 [doi]
LID - 113
AB  - In the olfactory bulb of adult rodents, local interneurons are constantly 
      replaced by immature precursors derived from the subventricular zone. Whether any 
      olfactory sensory process specifically relies on this cell renewal remains 
      largely unclear. By using the well known model of mating-induced imprinting to 
      avoid pregnancy block, which requires accessory olfactory bulb (AOB) function, we 
      demonstrate that this olfactory memory formation critically depends on the 
      presence of newborn granule neurons in this brain region. We show that, in adult 
      female mice, exposure to the male urine compounds involved in mate recognition 
      increases the number of new granule cells surviving in the AOB. This process is 
      modulated by male signals sensed through the vomeronasal organ and, in turn, 
      changes the activity of the downstream amygdaloid and hypothalamic nuclei 
      involved in the pregnancy block response. Chemical depletion of newly generated 
      bulbar interneurons causes strong impairment in mate recognition, thus resulting 
      in a high pregnancy failure rate to familiar mating male odors. Taken together, 
      our results indicate that adult neurogenesis is essential for specific brain 
      functions such as persistent odor learning and mate recognition.
FAU - Oboti, Livio
AU  - Oboti L
AD  - Department of Animal and Human Biology, University of Turin Turin, Italy.
FAU - Schellino, Roberta
AU  - Schellino R
FAU - Giachino, Claudio
AU  - Giachino C
FAU - Chamero, Pablo
AU  - Chamero P
FAU - Pyrski, Martina
AU  - Pyrski M
FAU - Leinders-Zufall, Trese
AU  - Leinders-Zufall T
FAU - Zufall, Frank
AU  - Zufall F
FAU - Fasolo, Aldo
AU  - Fasolo A
FAU - Peretto, Paolo
AU  - Peretto P
LA  - eng
PT  - Journal Article
DEP - 20110928
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC3182443
OTO - NOTNLM
OT  - AOB
OT  - Ara-C
OT  - Trpc2
OT  - male pheromones
OT  - medial amygdala
OT  - neurogenesis
OT  - olfactory imprinting
OT  - pregnancy block
EDAT- 2011/10/14 06:00
MHDA- 2011/10/14 06:01
PMCR- 2011/01/01
CRDT- 2011/10/14 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2011/09/05 00:00 [accepted]
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2011/10/14 06:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2011.00113 [doi]
PST - epublish
SO  - Front Neurosci. 2011 Sep 28;5:113. doi: 10.3389/fnins.2011.00113. eCollection 
      2011.