PMID- 21995180
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20130731
IS  - 1018-9068 (Print)
IS  - 1018-9068 (Linking)
VI  - 21
IP  - 6
DP  - 2011
TI  - Prevalence of uncontrolled severe persistent asthma in pneumology and allergy 
      hospital units in Spain.
PG  - 466-71
AB  - BACKGROUND: Severe persistent asthma is often poorly controlled and its 
      prevalence in pneumology and allergy hospital units in Spain is unknown. 
      OBJECTIVES: To determine the prevalence of uncontrolled severe persistent asthma 
      in hospital units in Spain and to describe the clinical characteristics of this 
      condition. METHODS: An observational, cross-sectional study was conducted in 164 
      Spanish hospital pneumology and allergology units. A record was made of all 
      patients with asthma and patients with uncontrolled severe asthma (diagnosed on 
      the basis of clinical criteria) seen in these units over 6 months. Information on 
      sociodemographic variables, clinical characteristics, pharmacological asthma 
      treatment, skin prick testing, total serum immunoglobulin E (IgE) levels, 
      pulmonary function (forced expiratory volume in the first second and forced vital 
      capacity), asthma control (Asthma Control Questionnaire [ACQ]), and quality of 
      life (Asthma Quality of Life Questionnaire) was collected. RESULTS: According to 
      the clinicians' judgement, 1423 out of 36 649 asthma patients (3.9%, 95% 
      confidence interval, 3.7%-4.1%]) had uncontrolled severe persistent asthma.These 
      patients had a mean (SD) ACQ score of 3.8 (1.0); 55.8% had a positive skin prick 
      test to common aeroallergens and 54.2% had high levels of total serum IgE.The 
      agreement between the assessment of asthma control based on clinicians' criteria 
      and according to the Global Initiative forAsthma (GINA) guidelines was moderate 
      (63.2%, Kic = 0.337), with an underestimation of asthma severity by clinicians; 
      53.2% of the patients classified as having controlled moderate to severe asthma 
      had uncontrolled severe persistent asthma according to GINA criteria. 
      CONCLUSIONS: There is a low prevalence of uncontrolled severe persistent asthma 
      in patients seen at hospital units in Spain according to clinical criteria, 
      although it should be noted that level of asthma control is overestimated by 
      clinicians.
FAU - Quirce, S
AU  - Quirce S
AD  - Hospital Universitario La Paz, Servicio de Alergia, Madrid, Spain.
FAU - Plaza, V
AU  - Plaza V
FAU - Picado, C
AU  - Picado C
FAU - Vennera, M
AU  - Vennera M
FAU - Casafont, J
AU  - Casafont J
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - J Investig Allergol Clin Immunol
JT  - Journal of investigational allergology & clinical immunology
JID - 9107858
SB  - IM
MH  - Asthma/*epidemiology
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hospitals/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Pulmonary Medicine/statistics & numerical data
MH  - Quality of Life
MH  - Spain/epidemiology
EDAT- 2011/10/15 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - J Investig Allergol Clin Immunol. 2011;21(6):466-71.