PMID- 21995421
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20191210
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 17
IP  - 3
DP  - 2012 May
TI  - Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) 
      increases conditioned rewarding effects of MDMA and drug-induced reinstatement.
PG  - 588-600
LID - 10.1111/j.1369-1600.2011.00382.x [doi]
AB  - Many adolescents often take ethanol (EtOH) in combination with 
      3,4-methylenedioxymethylamphetamine (MDMA). In the present work, we used a mouse 
      model to study the effect of repeated pre-exposure during adolescence to EtOH (2 
      g/kg), MDMA (10 or 20 mg/kg) or EtOH + MDMA on the rewarding and reinstating 
      effects of MDMA in the conditioned place preference (CPP) paradigm. Pre-exposure 
      to EtOH, MDMA or both increased the rewarding effects of a low dose of MDMA (1.25 
      mg/kg). These pre-treatments did not affect the acquisition of the CPP induced by 
      5 mg/kg of MDMA. However, the CPP was more persistent in mice pre-exposed to both 
      doses of MDMA or to EtOH + MDMA20. After extinction of the CPP induced by 5 mg/kg 
      of MDMA, reinstatement was observed in all groups with a priming dose of 2.5 
      mg/kg of MDMA, in the groups pre-exposed to EtOH or MDMA alone with a priming 
      dose of 1.25 mg/kg, and in the groups pre-treated with MDMA alone with a priming 
      dose of 0.625 mg/kg. Pre-treatment during adolescence with MDMA or EtOH induced 
      long-term changes in the level of biogenic amines [dihydroxyphenyl acetic acid, 
      homovanillic acid, dopamine turnover, serotonin (5-hydroxytryptamine, 5-HT) and 
      5-hydroxyindole acetic acid (5-HIAA) in the striatum, and 5-HT and 5-HIAA in the 
      cortex] after the first reinstatement test, although these effects depended on 
      the dose used during conditioning. These results suggest that exposure to EtOH 
      and MDMA during adolescence reinforces the addictive properties of MDMA.
CI  - (c) 2011 The Authors, Addiction Biology (c) 2011 Society for the Study of Addiction.
FAU - Ribeiro Do Couto, Bruno
AU  - Ribeiro Do Couto B
AD  - Departamento de Anatomia Humana y Psicobiologia, Facultad de Psicologia, 
      Universidad de Murcia, Campus Universitario de Espinardo, Spain.
FAU - Daza-Losada, Manuel
AU  - Daza-Losada M
FAU - Rodriguez-Arias, Marta
AU  - Rodriguez-Arias M
FAU - Nadal, Roser
AU  - Nadal R
FAU - Guerri, Consuelo
AU  - Guerri C
FAU - Summavielle, Teresa
AU  - Summavielle T
FAU - Minarro, Jose
AU  - Minarro J
FAU - Aguilar, Maria A
AU  - Aguilar MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111013
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Biogenic Amines)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Serotonin Agents)
RN  - 3K9958V90M (Ethanol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Biogenic Amines/metabolism
MH  - Central Nervous System Depressants/*pharmacology
MH  - Cerebral Cortex/metabolism
MH  - Conditioning, Psychological/*drug effects
MH  - Corpus Striatum/metabolism
MH  - Ethanol/*pharmacology
MH  - Extinction, Psychological/drug effects
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - *Reward
MH  - Serotonin Agents/*pharmacology
EDAT- 2011/10/15 06:00
MHDA- 2012/08/07 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - 10.1111/j.1369-1600.2011.00382.x [doi]
PST - ppublish
SO  - Addict Biol. 2012 May;17(3):588-600. doi: 10.1111/j.1369-1600.2011.00382.x. Epub 
      2011 Oct 13.