PMID- 21995494
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20111214
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 79
IP  - 1
DP  - 2012 Jan
TI  - Increased HLA class I and II diversity as 72 novel alleles are identified in 
      volunteers for the National Marrow Donor Program Registry in 2010.
PG  - 50-7
LID - 10.1111/j.1399-0039.2011.01788.x [doi]
AB  - Seventy-two novel human leukocyte antigen (HLA) class I and class II alleles are 
      described from volunteers for the 'Be The Match Registry(R)': 17 HLA-A alleles, 12 
      HLA-C alleles, 31 HLA-B alleles and 12 HLA-DRB1 alleles. Forty-six ( approximately  64%) of the 
      72 novel alleles are single-nucleotide substitution variants when compared with 
      their most homologous allele. Five of these single-nucleotide variants are silent 
      substitutions and one creates a non-expressed allele (B*44:108N). The remaining 
      novel alleles differ from their most similar allele by two to five nucleotide 
      substitutions. One of the novel HLA-C alleles (C*07:150Q) is of questionable 
      expression due to an insertion of 21 nucleotides starting at codon 143 that adds 
      seven amino acids to exon 3. An inter-locus gene conversion may have created the 
      novel allele HLA-A*23:31 that shares its codon differences with HLA-B*07:28. Some 
      of the new alleles encode novel codons and unique amino acid changes at 
      polymorphic positions in the HLA-A (codons 116 and 150), HLA-C (codon 114), HLA-B 
      (codons 11, 21, 35, 42, 48, 73, 98 and 170) and HLA-DRB1 (codon 29) loci.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Lazaro, A M
AU  - Lazaro AM
AD  - Department of Pediatrics and C.W. Bill Young Marrow Donor Research and 
      Recruitment Program, Georgetown University Medical Center, Washington, DC 20057, 
      USA.
FAU - Henry, J
AU  - Henry J
FAU - Ng, J
AU  - Ng J
FAU - Hurley, C K
AU  - Hurley CK
FAU - Posch, P E
AU  - Posch PE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111013
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Alleles
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - National Health Programs
MH  - *Polymorphism, Single Nucleotide
MH  - *Registries
MH  - *Tissue Donors
MH  - United States
EDAT- 2011/10/15 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01788.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Jan;79(1):50-7. doi: 10.1111/j.1399-0039.2011.01788.x. Epub 
      2011 Oct 13.