PMID- 21995572
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20191210
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 3
IP  - 10
DP  - 2011 Oct
TI  - Dendritic cells in the pathogenesis and treatment of human diseases: a Janus 
      Bifrons?
PG  - 1203-22
LID - 10.2217/imt.11.110 [doi]
AB  - Dendritic cells (DCs) represent the bridging cell compartment between a variety 
      of nonself antigens (i.e., microbial, cancer and vaccine antigens) and adaptive 
      immunity, orchestrating the quality and potency of downstream immune responses. 
      Because of the central role of DCs in the generation and regulation of immunity, 
      the modulation of DC function in order to shape immune responses is gaining 
      momentum. In this respect, recent advances in understanding DC biology, as well 
      as the required molecular signals for induction of T-cell immunity, have spurred 
      many experimental strategies to use DCs for therapeutic immunological approaches 
      for infections and cancer. However, when DCs lose control over such 'protective' 
      responses - by alterations in their number, phenotype and/or function - undesired 
      effects leading to allergy and autoimmune clinical manifestations may occur. 
      Novel therapeutic approaches have been designed and currently evaluated in order 
      to address DCs and silence these immunopathological processes. In this article we 
      present recent concepts of DC biology and some medical implications in view of 
      therapeutic opportunities.
FAU - Cools, Nathalie
AU  - Cools N
AD  - Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute 
      (Vaxinfectio), University of Antwerp, B-2610 Wilrijk, Belgium.
FAU - Petrizzo, Annacarmen
AU  - Petrizzo A
FAU - Smits, Evelien
AU  - Smits E
FAU - Buonaguro, Franco M
AU  - Buonaguro FM
FAU - Tornesello, Maria L
AU  - Tornesello ML
FAU - Berneman, Zwi
AU  - Berneman Z
FAU - Buonaguro, Luigi
AU  - Buonaguro L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Antigen Presentation
MH  - Autoimmunity
MH  - *Cancer Vaccines
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - *Immunotherapy
MH  - Infections/*immunology/therapy
MH  - Neoplasms/*immunology/pathology/therapy
EDAT- 2011/10/15 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.2217/imt.11.110 [doi]
PST - ppublish
SO  - Immunotherapy. 2011 Oct;3(10):1203-22. doi: 10.2217/imt.11.110.