PMID- 21997384
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20220310
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 69
IP  - 5
DP  - 2012 Mar
TI  - Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods 
      and regulatory aspects. Current knowledge assembled at an international workshop 
      at BfR, Germany.
PG  - 763-81
LID - 10.1007/s00018-011-0846-8 [doi]
AB  - Contact allergies are complex diseases, and one of the important challenges for 
      public health and immunology. The German 'Federal Institute for Risk Assessment' 
      hosted an 'International Workshop on Contact Dermatitis'. The scope of the 
      workshop was to discuss new discoveries and developments in the field of contact 
      dermatitis. This included the epidemiology and molecular biology of contact 
      allergy, as well as the development of new in vitro methods. Furthermore, it 
      considered regulatory aspects aiming to reduce exposure to contact sensitisers. 
      An estimated 15-20% of the general population suffers from contact allergy. 
      Workplace exposure, age, sex, use of consumer products and genetic 
      predispositions were identified as the most important risk factors. Research 
      highlights included: advances in understanding of immune responses to contact 
      sensitisers, the importance of autoxidation or enzyme-mediated oxidation for the 
      activation of chemicals, the mechanisms through which hapten-protein conjugates 
      are formed and the development of novel in vitro strategies for the 
      identification of skin-sensitising chemicals. Dendritic cell cultures and 
      structure-activity relationships are being developed to identify potential 
      contact allergens. However, the local lymph node assay (LLNA) presently remains 
      the validated method of choice for hazard identification and characterisation. At 
      the workshop the use of the LLNA for regulatory purposes and for quantitative 
      risk assessment was also discussed.
CI  - (c) The Author(s) 2011. This article is published with open access at 
      Springerlink.com
FAU - Peiser, M
AU  - Peiser M
AD  - Department of Product Safety, German Federal Institute for Risk Assessment (BfR), 
      Thielallee 88-92, 14195 Berlin, Germany.
FAU - Tralau, T
AU  - Tralau T
FAU - Heidler, J
AU  - Heidler J
FAU - Api, A M
AU  - Api AM
FAU - Arts, J H E
AU  - Arts JH
FAU - Basketter, D A
AU  - Basketter DA
FAU - English, J
AU  - English J
FAU - Diepgen, T L
AU  - Diepgen TL
FAU - Fuhlbrigge, R C
AU  - Fuhlbrigge RC
FAU - Gaspari, A A
AU  - Gaspari AA
FAU - Johansen, J D
AU  - Johansen JD
FAU - Karlberg, A T
AU  - Karlberg AT
FAU - Kimber, I
AU  - Kimber I
FAU - Lepoittevin, J P
AU  - Lepoittevin JP
FAU - Liebsch, M
AU  - Liebsch M
FAU - Maibach, H I
AU  - Maibach HI
FAU - Martin, S F
AU  - Martin SF
FAU - Merk, H F
AU  - Merk HF
FAU - Platzek, T
AU  - Platzek T
FAU - Rustemeyer, T
AU  - Rustemeyer T
FAU - Schnuch, A
AU  - Schnuch A
FAU - Vandebriel, R J
AU  - Vandebriel RJ
FAU - White, I R
AU  - White IR
FAU - Luch, A
AU  - Luch A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111014
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/immunology
MH  - Congresses as Topic
MH  - Dermatitis, Allergic Contact/epidemiology/*metabolism/prevention & control
MH  - Humans
MH  - Immunity, Innate
MH  - Keratinocytes/cytology/physiology
MH  - Local Lymph Node Assay
MH  - Natural Killer T-Cells/cytology/physiology
MH  - Risk Factors
PMC - PMC3276771
EDAT- 2011/10/15 06:00
MHDA- 2012/03/28 06:00
PMCR- 2011/10/14
CRDT- 2011/10/15 06:00
PHST- 2011/06/14 00:00 [received]
PHST- 2011/09/20 00:00 [accepted]
PHST- 2011/08/29 00:00 [revised]
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
PHST- 2011/10/14 00:00 [pmc-release]
AID - 846 [pii]
AID - 10.1007/s00018-011-0846-8 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2012 Mar;69(5):763-81. doi: 10.1007/s00018-011-0846-8. Epub 
      2011 Oct 14.