PMID- 21997600
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20211020
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Print)
IS  - 1064-7481 (Linking)
VI  - 20
IP  - 9
DP  - 2012 Sep
TI  - Early visuospatial deficits predict the occurrence of visual hallucinations in 
      autopsy-confirmed dementia with Lewy bodies.
PG  - 773-81
LID - 10.1097/JGP.0b013e31823033bc [doi]
AB  - OBJECTIVES: The current study explored the value of visuospatial findings for 
      predicting the occurrence of visual hallucinations (VH) in a sample of patients 
      with dementia with Lewy bodies (DLB) compared with patients with Alzheimer 
      disease (AD). PARTICIPANTS/MEASUREMENTS: Retrospective analysis of 55 
      autopsy-confirmed DLB and 55 demographically similar, autopsy-confirmed AD cases 
      determined whether severe initial visuospatial deficits on the WISC-R Block 
      Design subtest predicted the development of VH. Visuospatial deficits were 
      considered severe if Block Design z scores were 2.5 or more standard deviations 
      below the mean of a well-characterized normal control group (severe visuospatial 
      deficits [severe-VIS]; DLB: n = 35, AD: n = 26) and otherwise were considered 
      mild (mild visuospatial deficits [mild-VIS]; DLB: n = 20, AD: n = 29). RESULTS: 
      Forty percent of the severe-VIS DLB group had baseline VH compared with 0% of 
      mild-VIS DLB patients. Only 8% of the severe-VIS and 3% mild-VIS AD patients had 
      baseline VH. During the follow-up period (mean = 5.0 years), an additional 61% of 
      the severe-VIS but only 11% of the mild-VIS DLB patients developed VH. In that 
      period, 38% of the severe-VIS and 20% of the mild-VIS AD patients developed VH. 
      After considering initial MMSE score and rate of decline, logistic regression 
      analyses found that performance on Block Design significantly predicted the 
      presence of VH in the DLB group but not the AD group. CONCLUSIONS: The presence 
      of early, severe deficits on neuropsychological tests of visuospatial skill 
      increases the likelihood that patients with suspected DLB will develop the 
      prototypical DLB syndrome. The presence of such deficits may identify those DLB 
      patients whose syndrome is driven by alpha-synuclein pathology rather than AD 
      pathology and may inform treatment plans as well as future research.
FAU - Hamilton, Joanne M
AU  - Hamilton JM
AD  - Department of Neurosciences, University of California, San Diego, La Jolla, CA 
      92093, USA. jmhamilton@ucsd.edu
FAU - Landy, Kelly M
AU  - Landy KM
FAU - Salmon, David P
AU  - Salmon DP
FAU - Hansen, Lawrence A
AU  - Hansen LA
FAU - Masliah, Eliezer
AU  - Masliah E
FAU - Galasko, Douglas
AU  - Galasko D
LA  - eng
GR  - R01 NS049298/NS/NINDS NIH HHS/United States
GR  - AG05131/AG/NIA NIH HHS/United States
GR  - NS049298/NS/NINDS NIH HHS/United States
GR  - P50 AG005131/AG/NIA NIH HHS/United States
GR  - R01 NS049298-04/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
SB  - IM
MH  - Aged
MH  - Agnosia/complications/*psychology
MH  - Alzheimer Disease/complications/psychology
MH  - Autopsy/methods/statistics & numerical data
MH  - Female
MH  - Hallucinations/complications/*psychology
MH  - Humans
MH  - Lewy Body Disease/complications/diagnosis/*psychology
MH  - Male
MH  - Neuropsychological Tests/statistics & numerical data
MH  - Predictive Value of Tests
MH  - Psychomotor Performance
MH  - Retrospective Studies
PMC - PMC3260388
MID - NIHMS321453
EDAT- 2011/10/15 06:00
MHDA- 2013/01/18 06:00
PMCR- 2013/09/01
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - S1064-7481(12)61994-0 [pii]
AID - 10.1097/JGP.0b013e31823033bc [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2012 Sep;20(9):773-81. doi: 
      10.1097/JGP.0b013e31823033bc.