PMID- 21997694
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220310
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 35
IP  - 11
DP  - 2011 Nov
TI  - Pigmented spindle cell nevus: clues for differentiating it from spindle cell 
      malignant melanoma. A comprehensive survey including clinicopathologic, 
      immunohistochemical, and FISH studies.
PG  - 1733-42
LID - 10.1097/PAS.0b013e318229cf66 [doi]
AB  - Pigmented spindle cell nevus (PSCN), also known as Reed nevus, is a distinctive 
      melanocytic tumor that can show worrisome clinical and histologic features 
      mimicking a malignant melanoma. From a series of 46 pigmented spindle cell 
      melanocytic lesions, including 22 PSCN and 24 spindle cell malignant melanomas 
      (SCMMs), we collected clinical and histopathologic characteristics and evaluated 
      cell cycle and apoptosis regulators by immunohistochemistry. Moreover, 
      fluorescence in situ hybridization (FISH) using probes targeting 6p25 (RREB1), 
      11q13 (CCND1), 6q23 (MYB), and centromere 6 was performed. PSCN presented in 
      younger people, frequently in women, and were small lesions under 7 mm in 
      diameter affecting the lower limbs, whereas SCMMs arose more frequently in the 
      trunk, upper limbs, and head and neck region. Histologically, symmetry, good 
      lateral demarcation, and uniformity of cellular nests were significantly 
      differential features of PSCN, whereas pagetoid and adnexal spread were 
      frequently seen in both tumors. Immunohistochemical markers that significantly 
      differed from melanomas were Ki-67, cyclin D1, and survivin. FISH was positive in 
      1 of 15 PSCN and was negative in 4 of 15 SCMMs. These results correlated to a 
      sensitivity of 73% and a specificity of 93%. In conclusion, in the evaluation of 
      pigmented spindle cell melanocytic tumors, the integration of clinical and 
      histologic assessment is essential. However, ancillary techniques such as 
      proliferation antigen Ki-67, cyclin D1, survivin, and FISH can be useful as 
      adjunctive tools.
FAU - Diaz, Alba
AU  - Diaz A
AD  - Department of Pathology, Hospital Clinic, Institut d'Investigacions Biomediques 
      August Pi i Sunyer, University of Barcelona, Spain.
FAU - Valera, Alexandra
AU  - Valera A
FAU - Carrera, Cristina
AU  - Carrera C
FAU - Hakim, Sofia
AU  - Hakim S
FAU - Aguilera, Paula
AU  - Aguilera P
FAU - Garcia, Adriana
AU  - Garcia A
FAU - Palou, Josep
AU  - Palou J
FAU - Puig, Susana
AU  - Puig S
FAU - Malvehy, Josep
AU  - Malvehy J
FAU - Alos, Llucia
AU  - Alos L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cell Cycle Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apoptosis
MH  - Apoptosis Regulatory Proteins/analysis/genetics
MH  - Biomarkers, Tumor/analysis/genetics
MH  - Biopsy
MH  - Cell Cycle Proteins/analysis/genetics
MH  - Cell Proliferation
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - *Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/chemistry/*diagnosis/genetics/pathology
MH  - Middle Aged
MH  - Nevus, Spindle Cell/chemistry/*diagnosis/genetics/pathology
MH  - Predictive Value of Tests
MH  - Sensitivity and Specificity
MH  - Skin Neoplasms/chemistry/*diagnosis/genetics/pathology
MH  - Spain
MH  - Young Adult
EDAT- 2011/10/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 00000478-201111000-00015 [pii]
AID - 10.1097/PAS.0b013e318229cf66 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2011 Nov;35(11):1733-42. doi: 10.1097/PAS.0b013e318229cf66.