PMID- 21998394
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20211020
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 334
IP  - 6053
DP  - 2011 Oct 14
TI  - Successful transmission of a retrovirus depends on the commensal microbiota.
PG  - 245-9
LID - 10.1126/science.1210718 [doi]
AB  - To establish chronic infections, viruses must develop strategies to evade the 
      host's immune responses. Many retroviruses, including mouse mammary tumor virus 
      (MMTV), are transmitted most efficiently through mucosal surfaces rich in 
      microbiota. We found that MMTV, when ingested by newborn mice, stimulates a state 
      of unresponsiveness toward viral antigens. This process required the intestinal 
      microbiota, as antibiotic-treated mice or germ-free mice did not transmit 
      infectious virus to their offspring. MMTV-bound bacterial lipopolysaccharide 
      triggered Toll-like receptor 4 and subsequent interleukin-6 (IL-6)-dependent 
      induction of the inhibitory cytokine IL-10. Thus, MMTV has evolved to rely on the 
      interaction with the microbiota to induce an immune evasion pathway. Together, 
      these findings reveal the fundamental importance of commensal microbiota in viral 
      infections.
FAU - Kane, Melissa
AU  - Kane M
AD  - Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.
FAU - Case, Laure K
AU  - Case LK
FAU - Kopaskie, Karyl
AU  - Kopaskie K
FAU - Kozlova, Alena
AU  - Kozlova A
FAU - MacDearmid, Cameron
AU  - MacDearmid C
FAU - Chervonsky, Alexander V
AU  - Chervonsky AV
FAU - Golovkina, Tatyana V
AU  - Golovkina TV
LA  - eng
GR  - AI090084/AI/NIAID NIH HHS/United States
GR  - P30 DK042086/DK/NIDDK NIH HHS/United States
GR  - R01 AI090084/AI/NIAID NIH HHS/United States
GR  - P30 CA014599/CA/NCI NIH HHS/United States
GR  - DK42086/DK/NIDDK NIH HHS/United States
GR  - T32 AI065382-01/AI/NIAID NIH HHS/United States
GR  - R01 AI082418/AI/NIAID NIH HHS/United States
GR  - AI082418/AI/NIAID NIH HHS/United States
GR  - R01 CA134667/CA/NCI NIH HHS/United States
GR  - R56 AI090084/AI/NIAID NIH HHS/United States
GR  - T32GM007183/GM/NIGMS NIH HHS/United States
GR  - CA100383/CA/NCI NIH HHS/United States
GR  - R01 CA100383/CA/NCI NIH HHS/United States
GR  - T32 GM007183/GM/NIGMS NIH HHS/United States
GR  - T32 AI065382/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
CIN - Science. 2011 Oct 14;334(6053):168. PMID: 21998362
CIN - Nat Rev Microbiol. 2011 Dec;9(12):831. PMID: 22048739
MH  - Animals
MH  - Animals, Newborn
MH  - Anti-Bacterial Agents/pharmacology
MH  - Antibodies, Viral/biosynthesis
MH  - Antigens, Viral/immunology
MH  - *Bacterial Physiological Phenomena
MH  - Female
MH  - Germ-Free Life
MH  - *Immune Evasion
MH  - Interleukin-10/genetics/metabolism
MH  - Intestinal Mucosa/*virology
MH  - Intestines/*microbiology
MH  - Lipopolysaccharides/immunology/metabolism
MH  - Mammary Tumor Virus, Mouse/*immunology/*pathogenicity
MH  - *Metagenome
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/virology
MH  - Retroviridae Infections/immunology/*transmission/virology
MH  - Specific Pathogen-Free Organisms
MH  - Toll-Like Receptor 4/immunology/metabolism
MH  - Tumor Virus Infections/immunology/transmission/virology
MH  - Virus Replication
PMC - PMC3519937
MID - NIHMS425334
EDAT- 2011/10/15 06:00
MHDA- 2011/10/28 06:00
PMCR- 2012/12/11
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
PHST- 2012/12/11 00:00 [pmc-release]
AID - 334/6053/245 [pii]
AID - 10.1126/science.1210718 [doi]
PST - ppublish
SO  - Science. 2011 Oct 14;334(6053):245-9. doi: 10.1126/science.1210718.