PMID- 22000095
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20181201
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 48
IP  - 4
DP  - 2011 Oct
TI  - Initiation and reinitiation of anticoagulation therapy.
PG  - 295-301
LID - 10.1053/j.seminhematol.2011.08.007 [doi]
AB  - A thorough understanding of the pharmacology, pharmacokinetics, and 
      pharmacodynamics of the most commonly prescribed anticoagulants is necessary to 
      ensure optimal therapeutic outcomes and patient safety. Evidence is available to 
      guide some, but not all aspects of anticoagulation therapy initiation. Issues 
      related to the initiation of anticoagulation therapy, including the resumption of 
      therapy following interruption of anticoagulation for invasive procedures, are 
      reviewed. Initiating unfractionated heparin (UFH), low-molecular-weight heparin 
      (LMWH), or fondaparinux is challenging for patients with renal dysfunction and 
      obesity. UFH is preferred in patients with severe renal dysfunction. Morbidly 
      obese patients may require higher than usual prophylactic doses of LMWH. 
      Therapeutic doses of LMWH should be based on actual body weight, even in obese 
      patients. Currently available evidence does not demonstrate the superiority of 
      one initial warfarin dose over another. All anticoagulants increase the risk of 
      bleeding and should therefore only be initiated in appropriately selected 
      patients with sufficiently low underlying bleeding risk.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Witt, Daniel M
AU  - Witt DM
AD  - Kaiser Permanente Colorado, Aurora, CO 80011, USA. dan.m.witt@kp.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Polysaccharides)
RN  - J177FOW5JL (Fondaparinux)
SB  - IM
MH  - Anticoagulants/*administration & dosage/*pharmacokinetics
MH  - Fondaparinux
MH  - Hemorrhage/*chemically induced/drug therapy/metabolism
MH  - Heparin, Low-Molecular-Weight/administration & dosage/pharmacokinetics
MH  - Humans
MH  - Polysaccharides/administration & dosage/pharmacokinetics
EDAT- 2011/10/18 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - S0037-1963(11)00078-3 [pii]
AID - 10.1053/j.seminhematol.2011.08.007 [doi]
PST - ppublish
SO  - Semin Hematol. 2011 Oct;48(4):295-301. doi: 10.1053/j.seminhematol.2011.08.007.