PMID- 22001208
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20111031
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 585
IP  - 21
DP  - 2011 Nov 4
TI  - Menin prevents liver steatosis through co-activation of peroxisome 
      proliferator-activated receptor alpha.
PG  - 3403-8
LID - 10.1016/j.febslet.2011.09.043 [doi]
AB  - Fatty liver is strongly associated with metabolic syndrome. Here, we show that 
      the impaired hepatic expression of menin, the product of the MEN1 (multiple 
      endocrine neoplasia type 1) tumor suppressor gene, represents a common feature of 
      several fatty liver mouse models. The liver specific ablation of MEN1 gene 
      expression in healthy mice induced hepatic steatosis under high-fat dietary 
      conditions. Moreover, overexpression of menin in livers of steatotic db/db mice 
      reduced liver triglyceride accumulation. At the molecular level, we found that 
      menin acts synergistically with the nuclear receptor PPARalpha to control gene 
      expression of fatty acid oxidation. Collectively, these data suggest a crucial 
      role for menin as an integrator of the complex transcriptional network 
      controlling hepatic steatosis.
CI  - Copyright (c) 2011 Federation of European Biochemical Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Cheng, Peng
AU  - Cheng P
AD  - Department of General Surgery, Changhai Hospital, Second Military Medical 
      University, Shanghai 200433, People's Republic of China. dfbbcxjh@Gmail.com
FAU - Yang, Sheng Sheng
AU  - Yang SS
FAU - Hu, Xian Gui
AU  - Hu XG
FAU - Zhou, Xu Yu
AU  - Zhou XY
FAU - Zhang, Yi Jie
AU  - Zhang YJ
FAU - Jin, Gang
AU  - Jin G
FAU - Zhou, Ying Qi
AU  - Zhou YQ
LA  - eng
PT  - Journal Article
DEP - 20111012
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Men1 protein, mouse)
RN  - 0 (PPAR alpha)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Small Interfering)
SB  - IM
MH  - Animals
MH  - Down-Regulation/genetics
MH  - Fatty Liver/genetics/*metabolism/prevention & control
MH  - Gene Knockdown Techniques
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - Organ Specificity
MH  - PPAR alpha/*metabolism
MH  - Proto-Oncogene Proteins/deficiency/genetics/*metabolism
MH  - RNA, Small Interfering/genetics
EDAT- 2011/10/18 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2011/09/29 00:00 [revised]
PHST- 2011/09/30 00:00 [accepted]
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - S0014-5793(11)00748-4 [pii]
AID - 10.1016/j.febslet.2011.09.043 [doi]
PST - ppublish
SO  - FEBS Lett. 2011 Nov 4;585(21):3403-8. doi: 10.1016/j.febslet.2011.09.043. Epub 
      2011 Oct 12.