PMID- 22002004
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20220331
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Linking)
VI  - 24
IP  - 1
DP  - 2012 Jan
TI  - HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus.
PG  - 59-63
LID - 10.1097/MEG.0b013e32834d09d4 [doi]
AB  - OBJECTIVE: To determine the genetic profile of celiac disease (CD) in Libyan 
      children with type 1 diabetes as there are no data on the frequency of human 
      leukocyte antigen (HLA)-related CD-predisposing genes in diabetic patients in 
      Libya. METHODS: We randomly studied 218 Libyan type 1 diabetic children. The mean 
      age was 12.2+/-4.6 years; 56% were female patients. The mean duration of diabetes 
      was 4.7+/-4.0 years. All patients were screened for CD with IgA 
      tissue-transglutaminase (tTG) and endomysium antibodies. Patients with positive 
      immunological screen were programmed for a small-bowel biopsy. HLA-DRB1* and 
      HLA-DQB1* were genotyped in all tTG-positive patients. RESULTS: Twenty-seven 
      (12.4%) out of 218 patients with type1 diabetes had positive tTG, and 20 (9.2%) 
      of these patients were positive for endomysium antibodies. Five patients (5/27) 
      were already known cases of biopsy-proven CD. Biopsy was not performed in two 
      patients. One biopsy result was normal, whereas 19 biopsies demonstrated 
      morphological changes consistent with CD. Forty-eight percent of the 
      anti-tTG-positive group were homozygous for HLA-DQ2, whereas 75% of biopsy-proven 
      CD patients had HLA-DQ2, 21% had HLA-DQ2/DQ8, and 4% had HLA-DQ8. In addition, 
      the majority (70%) carried HLA-DQ2 linkage with HLA-DRB1*03. CONCLUSION: Overall, 
      biopsy-confirmed prevalence of CD was 11% (24 of 218). The present study confirms 
      that CD in the Libyan type 1 diabetic population is high when compared with 
      European and US studies, and for the first time we document that this population 
      shares similar HLA-DQ2 genotype. This supports the theory regarding the role of 
      the environment as an important factor in CD development in this part of the 
      world.
FAU - Ghawil, Millad
AU  - Ghawil M
AD  - Department of Pediatrics, DISM, University of Udine, Piazzale Santa Maria Delle 
      Misericordia 15, Udine, Italy. ghamillad@hotmail.com
FAU - Miotti, Valeria
AU  - Miotti V
FAU - Tonutti, Elio
AU  - Tonutti E
FAU - Tenore, Alfred
AU  - Tenore A
FAU - Hadeed, Ibtisam
AU  - Hadeed I
FAU - Sindici, Chiara
AU  - Sindici C
FAU - Visentini, Daniela
AU  - Visentini D
FAU - Morgham, Amel
AU  - Morgham A
FAU - Abusrewil, Sulieman
AU  - Abusrewil S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Reticulin)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
MH  - Adolescent
MH  - Autoantibodies/blood
MH  - Celiac Disease/complications/diagnosis/epidemiology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/complications/epidemiology/*genetics
MH  - Female
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Libya/epidemiology
MH  - Male
MH  - Reticulin/immunology
MH  - Transglutaminases/immunology
MH  - Young Adult
EDAT- 2011/10/18 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1097/MEG.0b013e32834d09d4 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2012 Jan;24(1):59-63. doi: 
      10.1097/MEG.0b013e32834d09d4.