PMID- 22002122
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20111017
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Oct 3
TI  - Polymorphisms associated with egg number at 300 days of age in chickens.
PG  - 2279-89
LID - 10.4238/2011.October.3.5 [doi]
AB  - We looked for variations that could be associated with chicken egg number at 300 
      days of age (EN300) in seven genes of the hypothalamic-pituitary-gonadal axis, 
      including gonadotrophin-releasing hormone-I (GnRH-I), GnRH receptor (GnRHR), 
      neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vasoactive intestinal 
      polypeptide (VIP), VIP receptor-1 (VIPR-1), prolactin (PRL), and the QTL region 
      between 87 and 105 cM of the Z chromosome. Ten mutations in the seven genes were 
      chosen to do marker-trait association analyses in a population comprising 1310 
      chickens, which were obtained from a company located in Guangdong Province of 
      China. The C1704887T of VIPR-1 was found to have a highly significant association 
      with EN300. The T5841629C of DRD2 and the C1715301T of VIPR-1 were significantly 
      associated with EN300. A highly significant association was also found between 
      the C1704887T-C1715301T haplotypes of VIPR-1 and EN300. H1H3 had the highest 
      EN300. Four PCR-RFLP variations in the candidate QTL region were selected to 
      investigate their genetic effects on EN300. The haplotypes of 
      T32742468C-G32742603A in this region showed a highly significant association with 
      EN300. Bioinformatics analyses showed that both T32742468C and G32742603A were 
      located in intron 1 of the SH3-domain GRB2-like 2 (SH3GL2) gene. We conclude that 
      five SNPs, including C1704887T and C1715301T of VIPR-1, T5841629C of DRD2, and 
      T32742468C and G32742603A of SH3GL2, would be useful as markers for breeding to 
      increase chicken EN300.
FAU - Xu, H P
AU  - Xu HP
AD  - Department of Animal Genetics, Breeding and Reproduction, College of Animal 
      Science, South China Agricultural University, Guangzhou, Guangdong, China.
FAU - Zeng, H
AU  - Zeng H
FAU - Zhang, D X
AU  - Zhang DX
FAU - Jia, X L
AU  - Jia XL
FAU - Luo, C L
AU  - Luo CL
FAU - Fang, M X
AU  - Fang MX
FAU - Nie, Q H
AU  - Nie QH
FAU - Zhang, X Q
AU  - Zhang XQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111003
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Receptors, LHRH)
RN  - 0 (Receptors, Vasoactive Intestinal Polypeptide, Type I)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Chickens/*genetics/metabolism
MH  - Female
MH  - *Hypothalamo-Hypophyseal System
MH  - Neuropeptide Y/genetics/metabolism
MH  - *Ovum
MH  - *Polymorphism, Genetic
MH  - Prolactin/genetics/metabolism
MH  - Receptors, Dopamine D2/genetics/metabolism
MH  - Receptors, LHRH/genetics/metabolism
MH  - Receptors, Vasoactive Intestinal Polypeptide, Type I/genetics/metabolism
MH  - Sex Chromosomes/*genetics
MH  - Vasoactive Intestinal Peptide/genetics/metabolism
EDAT- 2011/10/18 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - gmr1167 [pii]
AID - 10.4238/2011.October.3.5 [doi]
PST - epublish
SO  - Genet Mol Res. 2011 Oct 3;10(4):2279-89. doi: 10.4238/2011.October.3.5.