PMID- 2200253
OWN - NLM
STAT- MEDLINE
DCOM- 19900907
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 120
IP  - 2
DP  - 1990 Aug
TI  - Nifedipine and isosorbide dinitrate alone and in combination for patients with 
      chronic stable angina: a double-blind crossover study.
PG  - 303-7
AB  - Since not all patients tolerate beta-blockers, the efficacy of nifedipine and 
      isosorbide dinitrate was evaluated alone and in combination in patients with 
      stable angina pectoris. The study was a randomized double-blind crossover design 
      with patients titrated to maximally tolerated doses of both drugs. Phases 
      included isosorbide dinitrate alone, nifedipine alone, and isosorbide dinitrate 
      plus nifedipine in combination, with efficacy determined by stress testing. 
      Eleven men and one woman patient with a mean age of 60 years and a mean of five 
      anginal episodes/week completed the study. Patients were in New York Heart 
      Association (NYHA) classes I, II, and III. With nifedipine alone compared with 
      isosorbide dinitrate alone, patients had fewer angina attacks/week (p less than 
      0.02), exercised longer before experiencing angina (p less than 0.03), and had 
      less ST segment depression during (p less than 0.03) or after (p less than 0.05) 
      exercise. When patients received isosorbide dinitrate plus nifedipine, only time 
      to onset of angina during exercise (p less than 0.05) was significantly different 
      from the response with isosorbide dinitrate alone. Analysis of variance between 
      nifedipine and isosorbide dinitrate plus nifedipine was not significant. 
      Diastolic blood pressure with isosorbide dinitrate plus nifedipine (p less than 
      0.04) was lower than with isosorbide dinitrate alone. No significant differences 
      in systolic blood pressure were noted between the treatment groups. The drugs 
      alone and in combination were relatively well tolerated. Nifedipine alone may be 
      superior to isosorbide dinitrate alone. The combination of isosorbide dinitrate 
      plus nifedipine demonstrated no advantage over nifedipine alone compared with 
      isosorbide dinitrate alone.
FAU - Vlay, S C
AU  - Vlay SC
AD  - Department of Medicine, State University of New York, Stony Brook 11794.
FAU - Olson, L C
AU  - Olson LC
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Drug Combinations)
RN  - I9ZF7L6G2L (Nifedipine)
RN  - IA7306519N (Isosorbide Dinitrate)
SB  - IM
MH  - Angina Pectoris/*drug therapy/physiopathology
MH  - Chronic Disease
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Drug Combinations
MH  - Female
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Isosorbide Dinitrate/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Nifedipine/adverse effects/*therapeutic use
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
AID - 0002-8703(90)90073-7 [pii]
AID - 10.1016/0002-8703(90)90073-7 [doi]
PST - ppublish
SO  - Am Heart J. 1990 Aug;120(2):303-7. doi: 10.1016/0002-8703(90)90073-7.