PMID- 22002677
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20211020
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 459
IP  - 5
DP  - 2011 Nov
TI  - Aggressive B cell lymphomas of the gastrointestinal tract: clinicopathologic and 
      genetic analysis.
PG  - 495-502
LID - 10.1007/s00428-011-1153-3 [doi]
AB  - Aggressive B cell lymphomas of the gastrointestinal tract include Burkitt 
      lymphoma (BL), diffuse large B cell lymphoma, and B cell lymphoma, 
      unclassifiable, with features intermediate between DLBCL and BL. To investigate 
      the clinical characters of DLBCL/BL of the gastrointestinal (GI) tract, 101 cases 
      of aggressive B cell lymphoma of the GI tract were analyzed by 
      immunohistochemistry and fluorescence in situ hybridization (FISH) using break 
      apart probe for c-MYC gene. For cases with c-MYC rearrangement, additional FISH 
      studies with MYC/IgH fusion probe, BCL2 break apart probe, and BCL6 break apart 
      probe were performed. MYC rearrangement was detected in 23 of 101 cases of 
      aggressive B cell lymphomas (22.5%). The cases with MYC rearrangement were 
      divided into 14 BL, three DLBCL/BL, and six DLBCL. One of the three DLBCL/BL had 
      double translocation for MYC and BCL6 gene. Clinically, DLBCL/BL of the GI tract 
      was more akin to Burkitt lymphoma than it is to GI tract DLBCL with c-MYC 
      rearrangement. The overall prognosis of patients with DLBCL/BL was the worst 
      among aggressive B cell lymphomas. DLBCL/BL is uncommon category of B cell 
      lymphoma in the GI tract with aggressive clinical course despite of intensive 
      chemotherapy.
FAU - Choi, Song-Yi
AU  - Choi SY
AD  - Department of Pathology, Chungbuk National University Hospital, Cheongju, South 
      Korea.
FAU - Kim, Seok Jin
AU  - Kim SJ
FAU - Kim, Won Seog
AU  - Kim WS
FAU - Kim, Kihyun
AU  - Kim K
FAU - Ko, Young-Hyeh
AU  - Ko YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111015
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gastrointestinal Neoplasms/drug therapy/genetics/mortality/*pathology
MH  - Gene Rearrangement
MH  - Genes, myc
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/drug therapy/genetics/mortality/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 2011/10/18 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/05/05 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/08/31 00:00 [revised]
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 10.1007/s00428-011-1153-3 [doi]
PST - ppublish
SO  - Virchows Arch. 2011 Nov;459(5):495-502. doi: 10.1007/s00428-011-1153-3. Epub 2011 
      Oct 15.