PMID- 22003324
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20211020
IS  - 1550-9397 (Electronic)
IS  - 1550-9389 (Print)
IS  - 1550-9389 (Linking)
VI  - 7
IP  - 5 Suppl
DP  - 2011 Oct 15
TI  - Behavioral and genetic markers of sleepiness.
PG  - S19-21
LID - 10.5664/JCSM.1348 [doi]
AB  - Neurobehavioral responses to acute total and chronic partial sleep deprivation 
      occur in healthy adults and are particularly evident in vigilant attention 
      performance. There are large inter-individual differences in the degree of 
      cognitive deficits--such differences are manifested in proportionality between 
      the mean and variance as sleep loss progresses. It has recently been demonstrated 
      via laboratory experiments that differential neurobehavioral vulnerability to 
      sleep deprivation is not random--but rather is stable and trait-like--strongly 
      suggesting a phenotypic response with possible genotypic involvement. These 
      experiments also showed that vulnerability was not explained by subjects' 
      baseline functioning or a number of other potential predictors. Differential 
      vulnerability has been shown to extend to chronic partial sleep deprivation. One 
      potential genetic biomarker for such differential vulnerability is the human 
      leukocyte antigen (HLA) DQB1*0602, an allele which we recently demonstrated 
      predicts interindividual differences in sleepiness, physiological sleep, and 
      fatigue to chronic partial sleep deprivation in healthy adults. Determination of 
      biomarkers of individual differences to sleep loss will help identify those 
      individuals in the general population who are most in need of prevention of sleep 
      debt and in need of effective countermeasures for sleep loss; will further 
      understanding and management of vulnerability to excessive sleepiness due to 
      common sleep and medical disorders; and will inform public policies pertaining to 
      the need for adequate sleep.
FAU - Goel, Namni
AU  - Goel N
AD  - Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, PA 19104-6021, USA. 
      goel@mail.med.upenn.edu
FAU - Dinges, David F
AU  - Dinges DF
LA  - eng
GR  - R13 HL104874/HL/NHLBI NIH HHS/United States
GR  - R01 NR004281/NR/NINR NIH HHS/United States
GR  - R01 NR004281-15/NR/NINR NIH HHS/United States
GR  - NR004281/NR/NINR NIH HHS/United States
GR  - UL1RR024134/RR/NCRR NIH HHS/United States
GR  - UL1 RR024134/RR/NCRR NIH HHS/United States
GR  - R01 NR004281-16/NR/NINR NIH HHS/United States
GR  - HL104874/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - J Clin Sleep Med
JT  - Journal of clinical sleep medicine : JCSM : official publication of the American 
      Academy of Sleep Medicine
JID - 101231977
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Disorders of Excessive Somnolence/*diagnosis/etiology/*genetics
MH  - Genetic Markers
MH  - Humans
MH  - *Psychomotor Performance
MH  - Sleep/genetics
MH  - Sleep Deprivation/complications/*diagnosis/*genetics
MH  - Wakefulness/genetics
PMC - PMC3190416
EDAT- 2011/10/19 06:00
MHDA- 2012/03/06 06:00
PMCR- 2012/04/15
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
PHST- 2012/04/15 00:00 [pmc-release]
AID - 10.5664/JCSM.1348 [doi]
PST - ppublish
SO  - J Clin Sleep Med. 2011 Oct 15;7(5 Suppl):S19-21. doi: 10.5664/JCSM.1348.