PMID- 22005402
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20151119
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 106 Suppl 1
DP  - 2011 Oct
TI  - The effects of weight loss on adipokines and markers of inflammation in dogs.
PG  - S11-4
LID - 10.1017/S0007114511000560 [doi]
AB  - Evidence suggests that adipose tissue-derived adipokines induce mild inflammation 
      and may play a role in insulin resistance associated with diabetes. The present 
      study was designed to examine a series of adipokines and markers of inflammation 
      in dogs before and after a successful weight loss. The study included fasting 
      serum samples from twenty-five dogs before and after a weight-loss programme. 
      Serum C-reactive protein (CRP) and monocyte chemoattractant protein-1 (MCP-1) 
      were measured as indicators of chronic inflammation, while serum adipokines 
      including total adiponectin, high-molecular-weight (HMW) adiponectin, resistin 
      and leptin were also examined. Medians for CRP (before, 10.0 (interquartile range 
      5.4-15.0) mug/ml; after, 5.6 (interquartile range 3.8-7.0) mug/ml) and MCP-1 
      (before, 212 (interquartile range 157-288) ng/ml; after, 185 (interquartile range 
      143-215) ng/ml) decreased significantly after weight loss. Medians for resistin 
      showed a mild, yet significant reduction (before, 67.1 (interquartile range 
      44.4-88.5) pg/ml; after, 60.5 (interquartile range 32.3-67.1) pg/ml), while 
      leptin showed a dramatic decrease after weight loss (before, 18.9 (interquartile 
      range 10.8-35.4) ng/ml; after, 6.6 (interquartile range 3.9-10.2) ng/ml). Serum 
      total adiponectin and HMW adiponectin were unchanged on all analyses performed. 
      These data suggest that weight loss can decrease chronic inflammation; however, 
      the clinical implications of this decrease are not well elucidated in dogs. 
      Surprisingly, there was no increase in total or HMW serum adiponectin after 
      weight loss, as observed previously in human subjects. The lack of change in 
      total and HMW adiponectin might explain why insulin resistance and type 2 
      diabetes are less prevalent in obese dogs when compared with humans and cats.
FAU - Wakshlag, Joseph J
AU  - Wakshlag JJ
AD  - Department of Clinical Sciences, Cornell University College of Veterinary 
      Medicine, VMC 1-120, Box 34, Ithaca, NY 14853, USA.
FAU - Struble, Angela M
AU  - Struble AM
FAU - Levine, Corri B
AU  - Levine CB
FAU - Bushey, Jennifer J
AU  - Bushey JJ
FAU - Laflamme, Dorothy P
AU  - Laflamme DP
FAU - Long, Grace M
AU  - Long GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adipokines/*metabolism
MH  - Animals
MH  - Biomarkers
MH  - Dog Diseases/*metabolism
MH  - Dogs
MH  - Female
MH  - Inflammation/blood/metabolism/*veterinary
MH  - Male
MH  - Obesity/metabolism/*veterinary
MH  - Weight Loss/*physiology
EDAT- 2011/10/26 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0007114511000560 [pii]
AID - 10.1017/S0007114511000560 [doi]
PST - ppublish
SO  - Br J Nutr. 2011 Oct;106 Suppl 1:S11-4. doi: 10.1017/S0007114511000560.