PMID- 22005784
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20211020
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Apr
TI  - High concordance of subtypes of childhood acute lymphoblastic leukemia within 
      families: lessons from sibships with multiple cases of leukemia.
PG  - 675-81
LID - 10.1038/leu.2011.274 [doi]
AB  - Polymorphic genes have been linked to the risk of acute lymphoblastic leukemia 
      (ALL). Surrogate markers for a low burden of early childhood infections are also 
      related to increased risk for developing childhood ALL. It remains uncertain, 
      whether siblings of children with ALL have an increased risk of developing ALL. 
      This international collaboration identified 54 sibships with two (N = 51) or more 
      (N = 3) cases of childhood ALL (ages <18 years). The 5-year event-free survival 
      for 61 patients diagnosed after 1 January 1990 was 0.83 +/- 0.05. Ages at diagnosis 
      (Spearman correlation coefficient, r(S) = 0.41, P = 0.002) were significantly 
      correlated, but not WBCs (r(S) = 0.23, P = 0.11). In 18 sibships with successful 
      karyotyping in both cases, six were concordant for high-hyperdiploidy (N = 3), 
      t(12;21) [ETV6/RUNX1] (N = 1), MLL rearrangement (N = 1) or t(1;19)(q23/p13) (N = 
      1). Eleven sibships were ALL-subtype concordant, being T-cell ALL (T-ALL) (N = 5, 
      of a total of six sibships, where the first-born had T-ALL) or B-lineage ALL 
      belonging to the same cytogenetic subset (N = 6), a finding that differs 
      significantly from the expected chance distribution (kappa: 0.58; P < 0.0001). These 
      data indicate strong genetic and/or environmental risk factors for childhood ALL 
      that are restricted to specific ALL subtypes, which must be taken into account, 
      when performing epidemiological studies to reveal etiological factors.
FAU - Schmiegelow, K
AU  - Schmiegelow K
AD  - Pediatric Clinics, The Juliane Marie Centre, The University Hospital 
      Rigshospitalet, Copenhagen, Denmark. kschmiegelow@rh.dk
FAU - Lausten Thomsen, U
AU  - Lausten Thomsen U
FAU - Baruchel, A
AU  - Baruchel A
FAU - Pacheco, C E
AU  - Pacheco CE
FAU - Pieters, Rob
AU  - Pieters R
FAU - Pombo-de-Oliveira, M S
AU  - Pombo-de-Oliveira MS
FAU - Andersen, E W
AU  - Andersen EW
FAU - Rostgaard, K
AU  - Rostgaard K
FAU - Hjalgrim, H
AU  - Hjalgrim H
FAU - Pui, C-H
AU  - Pui CH
LA  - eng
GR  - P30 CA021765/CA/NCI NIH HHS/United States
GR  - P30 CA21765/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111018
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - Child, Preschool
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - Infant
MH  - Leukocyte Count
MH  - Male
MH  - Oncogene Proteins, Fusion/genetics
MH  - Precursor Cell Lymphoblastic 
      Leukemia-Lymphoma/classification/etiology/*genetics/mortality
MH  - Risk Factors
EDAT- 2011/10/19 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - leu2011274 [pii]
AID - 10.1038/leu.2011.274 [doi]
PST - ppublish
SO  - Leukemia. 2012 Apr;26(4):675-81. doi: 10.1038/leu.2011.274. Epub 2011 Oct 18.