PMID- 22005930
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20240327
IS  - 1476-5578 (Electronic)
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 17
IP  - 12
DP  - 2012 Dec
TI  - Genome-wide association study of Alzheimer's disease with psychotic symptoms.
PG  - 1316-27
LID - 10.1038/mp.2011.125 [doi]
AB  - Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and 
      are associated with more rapid cognitive decline and increased functional 
      deficits. They show heritability up to 61% and have been proposed as a marker for 
      a disease subtype suitable for gene mapping efforts. We undertook a combined 
      analysis of three genome-wide association studies (GWASs) to identify loci that 
      (1) increase susceptibility to an AD and subsequent psychotic symptoms; or (2) 
      modify risk of psychotic symptoms in the presence of neurodegeneration caused by 
      AD. In all, 1299 AD cases with psychosis (AD+P), 735 AD cases without psychosis 
      (AD-P) and 5659 controls were drawn from Genetic and Environmental Risk in AD 
      Consortium 1 (GERAD1), the National Institute on Aging Late-Onset Alzheimer's 
      Disease (NIA-LOAD) family study and the University of Pittsburgh Alzheimer 
      Disease Research Center (ADRC) GWASs. Unobserved genotypes were imputed to 
      provide data on >1.8 million single-nucleotide polymorphisms (SNPs). Analyses in 
      each data set were completed comparing (1) AD+P to AD-P cases, and (2) AD+P cases 
      with controls (GERAD1, ADRC only). Aside from the apolipoprotein E (APOE) locus, 
      the strongest evidence for association was observed in an intergenic region on 
      chromosome 4 (rs753129; 'AD+PvAD-P' P=2.85 x 10(-7); 'AD+PvControls' P=1.11 x 
      10(-4)). SNPs upstream of SLC2A9 (rs6834555, P=3.0 x 10(-7)) and within VSNL1 
      (rs4038131, P=5.9 x 10(-7)) showed strongest evidence for association with AD+P 
      when compared with controls. These findings warrant further investigation in 
      larger, appropriately powered samples in which the presence of psychotic symptoms 
      in AD has been well characterized.
FAU - Hollingworth, P
AU  - Hollingworth P
AD  - Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, 
      Neurosciences and Mental Health Research Institute, Department of Psychological 
      Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.
FAU - Sweet, R
AU  - Sweet R
FAU - Sims, R
AU  - Sims R
FAU - Harold, D
AU  - Harold D
FAU - Russo, G
AU  - Russo G
FAU - Abraham, R
AU  - Abraham R
FAU - Stretton, A
AU  - Stretton A
FAU - Jones, N
AU  - Jones N
FAU - Gerrish, A
AU  - Gerrish A
FAU - Chapman, J
AU  - Chapman J
FAU - Ivanov, D
AU  - Ivanov D
FAU - Moskvina, V
AU  - Moskvina V
FAU - Lovestone, S
AU  - Lovestone S
FAU - Priotsi, P
AU  - Priotsi P
FAU - Lupton, M
AU  - Lupton M
FAU - Brayne, C
AU  - Brayne C
FAU - Gill, M
AU  - Gill M
FAU - Lawlor, B
AU  - Lawlor B
FAU - Lynch, A
AU  - Lynch A
FAU - Craig, D
AU  - Craig D
FAU - McGuinness, B
AU  - McGuinness B
FAU - Johnston, J
AU  - Johnston J
FAU - Holmes, C
AU  - Holmes C
FAU - Livingston, G
AU  - Livingston G
FAU - Bass, N J
AU  - Bass NJ
FAU - Gurling, H
AU  - Gurling H
FAU - McQuillin, A
AU  - McQuillin A
CN  - GERAD Consortium
CN  - National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group
FAU - Holmans, P
AU  - Holmans P
FAU - Jones, L
AU  - Jones L
FAU - Devlin, B
AU  - Devlin B
FAU - Klei, L
AU  - Klei L
FAU - Barmada, M M
AU  - Barmada MM
FAU - Demirci, F Y
AU  - Demirci FY
FAU - DeKosky, S T
AU  - DeKosky ST
FAU - Lopez, O L
AU  - Lopez OL
FAU - Passmore, P
AU  - Passmore P
FAU - Owen, M J
AU  - Owen MJ
FAU - O'Donovan, M C
AU  - O'Donovan MC
FAU - Mayeux, R
AU  - Mayeux R
FAU - Kamboh, M I
AU  - Kamboh MI
FAU - Williams, J
AU  - Williams J
LA  - eng
GR  - P30 AG010124/AG/NIA NIH HHS/United States
GR  - P30 AG028377/AG/NIA NIH HHS/United States
GR  - G0902227/MRC_/Medical Research Council/United Kingdom
GR  - P50 AG005142/AG/NIA NIH HHS/United States
GR  - R01 AG027224-04/AG/NIA NIH HHS/United States
GR  - P50 AG005133-23/AG/NIA NIH HHS/United States
GR  - P30 AG010161/AG/NIA NIH HHS/United States
GR  - R01 AG041797/AG/NIA NIH HHS/United States
GR  - P50 AG005138/AG/NIA NIH HHS/United States
GR  - P50 AG016582/AG/NIA NIH HHS/United States
GR  - P30AG028377/AG/NIA NIH HHS/United States
GR  - P50AG05138/AG/NIA NIH HHS/United States
GR  - P30 AG013854/AG/NIA NIH HHS/United States
GR  - P50AG05134/AG/NIA NIH HHS/United States
GR  - P30AG028383/AG/NIA NIH HHS/United States
GR  - P50AG005133/AG/NIA NIH HHS/United States
GR  - P50AG016582/AG/NIA NIH HHS/United States
GR  - P50AG08702/AG/NIA NIH HHS/United States
GR  - P30 AG010133/AG/NIA NIH HHS/United States
GR  - U24 AG021886/AG/NIA NIH HHS/United States
GR  - P50 AG008702/AG/NIA NIH HHS/United States
GR  - P50AG165574/AG/NIA NIH HHS/United States
GR  - P50AG016579/AG/NIA NIH HHS/United States
GR  - 082604/WT_/Wellcome Trust/United Kingdom
GR  - P01 AG003991/AG/NIA NIH HHS/United States
GR  - P50 AG005681/AG/NIA NIH HHS/United States
GR  - P01AG05138/AG/NIA NIH HHS/United States
GR  - P30 AG013846/AG/NIA NIH HHS/United States
GR  - U24 AG056270/AG/NIA NIH HHS/United States
GR  - P30AG10124/AG/NIA NIH HHS/United States
GR  - P30AG12300/AG/NIA NIH HHS/United States
GR  - P50AG05142/AG/NIA NIH HHS/United States
GR  - P30AG13854/AG/NIA NIH HHS/United States
GR  - R01 MH057881/MH/NIMH NIH HHS/United States
GR  - P01AG03991/AG/NIA NIH HHS/United States
GR  - P50 AG005136/AG/NIA NIH HHS/United States
GR  - P30 AG012300/AG/NIA NIH HHS/United States
GR  - U24AG021886/AG/NIA NIH HHS/United States
GR  - G0800509/MRC_/Medical Research Council/United Kingdom
GR  - HHSN268200782096C/HG/NHGRI NIH HHS/United States
GR  - R01AG027224/AG/NIA NIH HHS/United States
GR  - P01AG02219/AG/NIA NIH HHS/United States
GR  - P50 AG005134/AG/NIA NIH HHS/United States
GR  - P30 AG008017/AG/NIA NIH HHS/United States
GR  - P30AG013846/AG/NIA NIH HHS/United States
GR  - U24 AG026395/AG/NIA NIH HHS/United States
GR  - R01AG030653/AG/NIA NIH HHS/United States
GR  - G0300429/MRC_/Medical Research Council/United Kingdom
GR  - P30AG008017/AG/NIA NIH HHS/United States
GR  - P30AG010133/AG/NIA NIH HHS/United States
GR  - P50AG05136/AG/NIA NIH HHS/United States
GR  - P50 AG005133/AG/NIA NIH HHS/United States
GR  - P01 AG002219/AG/NIA NIH HHS/United States
GR  - R01 AG030653/AG/NIA NIH HHS/United States
GR  - R01 AG027224/AG/NIA NIH HHS/United States
GR  - P30AG10161/AG/NIA NIH HHS/United States
GR  - WT_/Wellcome Trust/United Kingdom
GR  - U24AG026395/AG/NIA NIH HHS/United States
GR  - P50AG05681/AG/NIA NIH HHS/United States
GR  - 095317/WT_/Wellcome Trust/United Kingdom
GR  - P30 AG028383/AG/NIA NIH HHS/United States
GR  - R01 AG030653-04/AG/NIA NIH HHS/United States
GR  - MC_U123160657/MRC_/Medical Research Council/United Kingdom
GR  - AG027224/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111018
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Apolipoproteins E)
RN  - 0 (DNA, Intergenic)
RN  - 0 (Glucose Transport Proteins, Facilitative)
RN  - 0 (Neurocalcin)
RN  - 0 (SLC2A9 protein, human)
RN  - 0 (VSNL1 protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/complications/*genetics/*psychology
MH  - Apolipoproteins E/genetics
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 4/genetics
MH  - DNA, Intergenic/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genome-Wide Association Study/methods/*statistics & numerical data
MH  - Glucose Transport Proteins, Facilitative/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurocalcin/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Psychotic Disorders/complications/diagnosis/*genetics
PMC - PMC3272435
MID - NIHMS330566
FIR - Harold, Denise
IR  - Harold D
FIR - Abraham, Richard
IR  - Abraham R
FIR - Hollingworth, Paul
IR  - Hollingworth P
FIR - Sims, Rebecca
IR  - Sims R
FIR - Gerrish, Amy
IR  - Gerrish A
FIR - Hamshere, Marian
IR  - Hamshere M
FIR - Pahwa, Jaspreet Singh
IR  - Pahwa JS
FIR - Moskvina, Valentina
IR  - Moskvina V
FIR - Dowzell, Kimberley
IR  - Dowzell K
FIR - Williams, Amy
IR  - Williams A
FIR - Jones, Nicola
IR  - Jones N
FIR - Thomas, Charlene
IR  - Thomas C
FIR - Stretton, Alexandra
IR  - Stretton A
FIR - Morgan, Angharad
IR  - Morgan A
FIR - Lovestone, Simon
IR  - Lovestone S
FIR - Powell, John
IR  - Powell J
FIR - Proitsi, Petroula
IR  - Proitsi P
FIR - Lupton, Michelle K
IR  - Lupton MK
FIR - Brayne, Carol
IR  - Brayne C
FIR - Rubinsztein, David C
IR  - Rubinsztein DC
FIR - Gill, Michael
IR  - Gill M
FIR - Lawlor, Brian
IR  - Lawlor B
FIR - Lynch, Aoibhinn
IR  - Lynch A
FIR - Morgan, Kevin
IR  - Morgan K
FIR - Brown, Kristelle
IR  - Brown K
FIR - Passmore, Peter
IR  - Passmore P
FIR - Craig, David
IR  - Craig D
FIR - McGuinness, Bernadette
IR  - McGuinness B
FIR - Todd, Stephen
IR  - Todd S
FIR - Johnston, Janet
IR  - Johnston J
FIR - Holmes, Clive
IR  - Holmes C
FIR - Mann, David
IR  - Mann D
FIR - Smith, A David
IR  - Smith A
FIR - Love, Seth
IR  - Love S
FIR - Kehoe, Patrick G
IR  - Kehoe PG
FIR - Hardy, John
IR  - Hardy J
FIR - Mead, Simon
IR  - Mead S
FIR - Fox, Nick
IR  - Fox N
FIR - Rossor, Martin
IR  - Rossor M
FIR - Collinge, John
IR  - Collinge J
FIR - Maier, Wolfgang
IR  - Maier W
FIR - Jessen, Frank
IR  - Jessen F
FIR - Heun, Reiner
IR  - Heun R
FIR - Kolsch, Heike
IR  - Kolsch H
FIR - Schurmann, Britta
IR  - Schurmann B
FIR - van den Bussche, Hendrik
IR  - van den Bussche H
FIR - Heuser, Isabella
IR  - Heuser I
FIR - Kornhuber, Johannes
IR  - Kornhuber J
FIR - Wiltfang, Jens
IR  - Wiltfang J
FIR - Dichgans, Martin
IR  - Dichgans M
FIR - Frolich, Lutz
IR  - Frolich L
FIR - Hampel, Harald
IR  - Hampel H
FIR - Hull, Michael
IR  - Hull M
FIR - Rujescu, Dan
IR  - Rujescu D
FIR - Goate, Alison
IR  - Goate A
FIR - Kauwe, John S K
IR  - Kauwe JS
FIR - Cruchaga, Carlos
IR  - Cruchaga C
FIR - Nowotny, Petra
IR  - Nowotny P
FIR - Morris, John C
IR  - Morris JC
FIR - Mayo, Kevin
IR  - Mayo K
FIR - Livingston, Gill
IR  - Livingston G
FIR - Bass, Nicholas J
IR  - Bass NJ
FIR - Gurling, Hugh
IR  - Gurling H
FIR - McQuillin, Andrew
IR  - McQuillin A
FIR - Gwilliam, Rhian
IR  - Gwilliam R
FIR - Deloukas, Panagiotis
IR  - Deloukas P
FIR - Al-Chalabi, Ammar
IR  - Al-Chalabi A
FIR - Shaw, Christopher E
IR  - Shaw CE
FIR - Singleton, Andrew B
IR  - Singleton AB
FIR - Guerreiro, Rita
IR  - Guerreiro R
FIR - Muhleisen, Thomas W
IR  - Muhleisen TW
FIR - Nothen, Markus M
IR  - Nothen MM
FIR - Moebus, Susanne
IR  - Moebus S
FIR - Jockel, Karl-Heinz
IR  - Jockel KH
FIR - Klopp, Norman
IR  - Klopp N
FIR - Wichmann, H-Erich
IR  - Wichmann HE
FIR - Carrasquillo, Minerva M
IR  - Carrasquillo MM
FIR - Pankratz, V Shane
IR  - Pankratz V
FIR - Younkin, Steven G
IR  - Younkin SG
FIR - Holmans, Peter
IR  - Holmans P
FIR - O'Donovan, Michael
IR  - O'Donovan M
FIR - Owen, Michael J
IR  - Owen MJ
FIR - Williams, Julie
IR  - Williams J
FIR - Green, Robert
IR  - Green R
FIR - Kowall, Neil
IR  - Kowall N
FIR - Farrer, Lindsay
IR  - Farrer L
FIR - Williamson, Jennifer
IR  - Williamson J
FIR - Santana, Vincent
IR  - Santana V
FIR - Schmechel, Donald
IR  - Schmechel D
FIR - Gaskel, Peter
IR  - Gaskel P
FIR - Ghetti, Bernardino
IR  - Ghetti B
FIR - Farlow, Martin R
IR  - Farlow MR
FIR - Horner, Kelly
IR  - Horner K
FIR - Growdon, John H
IR  - Growdon JH
FIR - Blacker, Deborah
IR  - Blacker D
FIR - Tanzi, Rudolph E
IR  - Tanzi RE
FIR - Hyman, Bradley T
IR  - Hyman BT
FIR - Boeve, Bradley
IR  - Boeve B
FIR - Kuntz, Karen
IR  - Kuntz K
FIR - Norgaard, Lindsay
IR  - Norgaard L
FIR - Larson, Nathan
IR  - Larson N
FIR - Kistler, Dana
IR  - Kistler D
FIR - Parfitt, Fracine
IR  - Parfitt F
FIR - Haddow, Jenny
IR  - Haddow J
FIR - Silverman, Jeremy
IR  - Silverman J
FIR - Schnaider Beeri, Michal
IR  - Schnaider Beeri M
FIR - Sano, Mary
IR  - Sano M
FIR - Wang, Joy
IR  - Wang J
FIR - Lally, Rachel
IR  - Lally R
FIR - Johnson, Nancy
IR  - Johnson N
FIR - Mesulum, Marcel
IR  - Mesulum M
FIR - Weintraub, Sandra
IR  - Weintraub S
FIR - Bigio, Eileen
IR  - Bigio E
FIR - Kaye, Jeffery
IR  - Kaye J
FIR - Kramer, Patricia
IR  - Kramer P
FIR - Payne-Murphy, Jessica
IR  - Payne-Murphy J
FIR - Bennett, David
IR  - Bennett D
FIR - Jacobs, Holli
IR  - Jacobs H
FIR - Chang, Jeen-Soo
IR  - Chang JS
FIR - Arends, Danielle
IR  - Arends D
FIR - Harrell, Lindy
IR  - Harrell L
FIR - Bartzokis, George
IR  - Bartzokis G
FIR - Cummings, Jeffery
IR  - Cummings J
FIR - Lu, Po H
IR  - Lu PH
FIR - Toland, Usha
IR  - Toland U
FIR - Smith, Charles
IR  - Smith C
FIR - Brickhouse, Alise
IR  - Brickhouse A
FIR - Trojanowski, John
IR  - Trojanowski J
FIR - Van Deerlin, Vivianna
IR  - Van Deerlin V
FIR - McCarty Wood, Elisabeth
IR  - McCarty Wood E
FIR - Lopez, Oscar L
IR  - Lopez OL
FIR - Sweet, Robert A
IR  - Sweet RA
FIR - Chui, I Helena
IR  - Chui IH
FIR - Varpetian, Arousiak
IR  - Varpetian A
FIR - Diaz-Arrastia, Ramon
IR  - Diaz-Arrastia R
FIR - Rosenberg, Roger
IR  - Rosenberg R
FIR - Davis, Barbara
IR  - Davis B
FIR - Bird, Thomas
IR  - Bird T
FIR - Rumbaugh, Malia
IR  - Rumbaugh M
FIR - Schellenberg, Gerard D
IR  - Schellenberg GD
FIR - Raskind, Murray
IR  - Raskind M
FIR - Goate, Alison
IR  - Goate A
FIR - Morris, John
IR  - Morris J
FIR - Norton, Joanne
IR  - Norton J
FIR - Levitch, Denise
IR  - Levitch D
FIR - Grant, Betsy
IR  - Grant B
FIR - Coats, Mary
IR  - Coats M
EDAT- 2011/10/19 06:00
MHDA- 2013/05/08 06:00
PMCR- 2012/12/01
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - mp2011125 [pii]
AID - 10.1038/mp.2011.125 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2012 Dec;17(12):1316-27. doi: 10.1038/mp.2011.125. Epub 2011 Oct 
      18.